191218-42-5

Basic information

• Product Name: 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-
• CAS NO: 191218-42-5
• Molecular Formula: C14H9FN2O
• Molecular Weight: 240.237
• Mol File: 191218-42-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-(191218-42-5)
• EPA Substance Registry System: 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-fluorophenyl)-(191218-42-5)

Safety Data

• Hazardous Substances Data: 191218-42-5(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 201230-82-2 carbon monoxide 
• 124-38-9 carbon dioxide 
• 1736-31-8 ethyl 3-(4-fluorophenyl)propiolate 
• 22288-66-0 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione 
• 1765-93-1 4-fluoroboronic acid 
• 1999-00-4 ethyl 3-(4'-fluorophenyl)-3-oxopropionate 
• 766-98-3 1-ethynyl-4-fluorobenzene 

Relevant articles and documents

Method for synthesizing pyrimidinone compound under participation of CO2

The invention provides a method for synthesizing a pyrimidinone compound under the participation of CO2, the structural formula of the pyrimidinone compound is shown as a formula (I), and a reaction substrate is shown as a formula (II); wherein R1, R2 and

Manganese-Catalyzed Carbonylative Annulations for Redox-Neutral Late-Stage Diversification

An inexpensive, nontoxic manganese catalyst enabled unprecedented redox-neutral carbonylative annulations under ambient pressure. The manganese catalyst outperformed all other typically used base and precious-metal catalysts. The outstanding versatility o

Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα

A strategy of scaffold-hopping of bioactive natural products, flavones and isoflavones, leading to target-based discovery of potent anticancer agents has been reported for the first time. Scaffold-hopped flavones, 2-aryl-4H-pyrido[1,2-a]pyrimidin-4-ones and the scaffold-hopped isoflavones, 3-aryl-pyrido[1,2-a]pyrimidin-4-ones were synthesized via Pd-catalyzed activation–arylation methods. Most of the compounds were found to exhibit pronounced human topoisomerase IIα (hTopoIIα) inhibitory activities and several compounds were found to be more potent than etoposide (a hTopoIIα-inhibiting anticancer drug). These classes of compounds were found to be hTopoIIα-selective catalytic inhibitors while not interfering with topoisomerase I and interacted with DNA plausibly in groove domain. Cytotoxicities against various cancer cells, low toxicity in normal cells, and apoptotic effects were observed. Interestingly, compared to parent flavones/isoflavones, their scaffold-hopped analogs bearing alike functionalities showed significant/enhanced hTopoIIα-inhibitory and cytotoxic properties, indicating the importance of a natural product-based scaffold-hopping strategy in the drug discovery.