19128-85-9

Basic information

• Product Name: Butanoic acid, 2-phenoxy-, (S)-
• Synonyms: (S)-2-phenoxybutanoic acid;L-2-phenoxy-butyric acid;2,6-di(propan-2-yl)phenyl 2-(4-methylpiperazin-1-yl)propanoate dihydrochloride;L-2-Phenoxy-buttersaeure;FC 646;(S)-2-phenoxybutyric acid;(2S)-2-phenoxybutanoic acid
• CAS NO: 19128-85-9
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 19128-85-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 81-82 °C
• Boiling Point: 258.0±0.0 °C(Predicted)
• Density: 1.140±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Butanoic acid, 2-phenoxy-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-phenoxy-, (S)-(19128-85-9)
• EPA Substance Registry System: Butanoic acid, 2-phenoxy-, (S)-(19128-85-9)

Safety Data

• Hazardous Substances Data: 19128-85-9(Hazardous Substances Data)

Upstream product

• 13794-14-4 2-phenoxybutyric acid 
• 591-50-4 iodobenzene 
• 3347-90-8 (2S)-2-hydroxybutanoic acid 
• 90843-51-9 α-phenoxy-2-butenoic acid 
• 108-95-2 phenol 
• 937025-54-2 (Z)-α-phenoxybutenoic acid 

Relevant articles and documents

OXA-SPIRODIPHOSPHINE LIGAND AND METHOD FOR ASYMMETRIC HYDROGENATION OF alpha, beta-UNSATURATED CARBOXYLIC ACIDS

The present invention provides an oxa-spirodiphosphine ligand having a structure of general Formula (I) below: wherein in general Formula (I), R1, R2, R3 and R4 are the same, and are alkyl, alkoxy, aryl, aryloxy

Oxa-spiral diphosphine ligand and application thereof in alpha, beta-unsaturated carboxylic acid asymmetric hydrogenation

The invention provides an oxa-spiral diphosphine ligand. The oxa-spiral diphosphine ligand has a structure shown by a general formula (I) as shown in description, wherein R1, R2, R3 and R4 in the general formula (I) are same and are alkyl, alkoxy, aryl, aroxyl, or hydrogen atoms; R1, R2, R3 and R4 comprise forms of ring formation, non-ring formation, any two ring formation or multiple-ring formation between pairs; R5 and R6 are alkyl, aryl or hydrogen atoms; and R7 and R8 are alkyl or benzyl or aryl. The invention further provides application of the oxa-spiral diphosphine ligand O-SDP in the alpha, beta-unsaturated carboxylic acid asymmetric hydrogenation. A complex of the oxa-spiral diphosphine ligand O-SDP and ruthenium has excellent activity and enantioselectivity in the asymmetric hydrogenation of the alpha, beta-unsaturated carboxylic acid in multiple types, and a chiral carboxylic acid product is obtained with the enantioselectivity being up to 99%. The synthesis method can be applied to the construction of a core skeleton of chemical molecules with important activity, wherein the chemical molecules comprise Paroxetine, Femoxetine, nipecotic acid and Sacubitril.

Asymmetric hydrogenation of α,β-unsaturated carboxylic acids catalyzed by ruthenium(II) complexes of spirobifluorene diphosphine (SFDP) ligands

The ruthenium diacetate complexes ligated by chiral spirobifluorene diphosphines (SFDP) were very effective catalysts for the asymmetric hydrogenation of tiglic acid derivatives and α-methylcinnamic acid derivatives with high activities and excellent enantioselectivities (up to 98% ee). The α-aryloxybutenoic acids can also be hydrogenated by these catalysts to provide the corresponding saturated α-aryloxybutanoic acids in high yields (89-93%) and enantioselectivities (up to 95% ee). In this reaction, the SFDP ligand with para-methyl groups on the P-phenyl rings gave the best results.