191347-94-1

Basic information

• Product Name: (R)-tert-butyl 3-formylpyrrolidine-1-carboxylate
• Synonyms: (R)-tert-butyl 3-formylpyrrolidine-1-carboxylate;(3R)-3-Formyl-1-pyrrolidinecarboxylic acid tert-butyl ester;R-1-Boc-3-pyrrolidinecarbaldehyde;tert-butyl (3R)-3-forMylpyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-forMyl-, 1,1-diMethylethyl ester, (R)-;(R)-3-forMyl-1-Boc-pyrrolidine
• CAS NO: 191347-94-1
• Molecular Formula: C₁₀H₁₇NO₃
• Molecular Weight: 199.248
• Mol File: 191347-94-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 276.3 °C at 760 mmHg
• Flash Point: 120.9 °C
• Appearance: /
• Density: 1.148
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.44±0.40(Predicted)
• CAS DataBase Reference: (R)-tert-butyl 3-formylpyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 3-formylpyrrolidine-1-carboxylate(191347-94-1)
• EPA Substance Registry System: (R)-tert-butyl 3-formylpyrrolidine-1-carboxylate(191347-94-1)

Safety Data

• Hazardous Substances Data: 191347-94-1(Hazardous Substances Data)

Usage

General Description

"(R)-tert-butyl 3-formylpyrrolidine-1-carboxylate" is a chemical compound with a molecular formula of C10H17NO3. It is an ester derivative of pyrrolidine-1-carboxylic acid, which is commonly used in the synthesis of pharmaceuticals and other organic compounds. (R)-tert-butyl 3-formylpyrrolidine-1-carboxylate is a chiral molecule, meaning it has a non-superimposable mirror image, and the (R)- designation indicates that it has a certain spatial arrangement of its atoms. The tert-butyl group on the molecule provides steric hindrance, which can influence the reactivity and stability of the compound. Its aldehyde functional group makes it a versatile intermediate in organic synthesis, and it can participate in a variety of chemical reactions. Overall, "(R)-tert-butyl 3-formylpyrrolidine-1-carboxylate" is an important compound with potential applications in the pharmaceutical and chemical industries.

Upstream product

• 201230-82-2 carbon monoxide 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 73286-71-2 N-(tert-butoxycarbonyl)-2,3-dihydropyrrole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 

Downstream Products

• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 1204677-48-4 (R)-3-((S)-hydroxyphenylmethyl)pyrrolidine-1-carboxylic acid t-butyl ester 
• 1204677-49-5 (R)-3-((R)-hydroxyphenylmethyl)pyrrolidine-1-carboxylic acid t-butyl ester 
• 1185165-40-5 tert-butyl (3S)-3-vinylpyrrolidine-1-carboxylate 
• 1204671-67-9 C₁₈H₂₁NO 
• 1204671-63-5 C₁₇H₁₈ClNO 
• 1204672-31-0 C₁₇H₁₈ClNO 
• 1204671-46-4 (R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate 
• 1204672-60-5 C₁₇H₁₈ClNO 

Relevant articles and documents

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Highly selective bisphosphine ligands for asymmetric hydroformylation of heterocyclic olefins

The bisphosphine ligand 1c is highly efficient and selective for the asymmetric hydroformylation (AHF) of dihydrofuran and pyrrolines. The AHF of 2,3-dihydrofuran yielded the 2-carbaldehyde in up to 93% ee. The remarkable highest regioselectivity of 2,5-dihydrofuran was obtained to date up to 499 β-isomer/α-isomer with ligand 1c. Furthermore, the highest 96% and 92% ee values were accomplished using the same catalytic system in the AHF of N-Boc pyrroline 11 and 14.