19145-60-9Relevant articles and documents
Utility of iron nanoparticles and a solution-phase iron species for the: N-demethylation of alkaloids
Awalt, Jon Kyle,Lam, Raymond,Kellam, Barrie,Graham, Bim,Scammells, Peter J.,Singer, Robert D.
supporting information, p. 2587 - 2594 (2017/07/17)
The N-demethylation of selected N-methylalkaloids using a modified Polonovski reaction can be accomplished using a novel green methodology employing nanoscale zero-valent iron, nZVI, in isopropanol. Use of nZVI promotes a much faster conversion to N-demethylated products due to much higher surface area on the metal surface as shown by SEM analysis. Rates of conversion can be further enhanced using catalytic quantities of the solubilised iron(0) species triiron dodecacarbonyl, Fe3(CO)12.
NOVEL COMPOUNDS
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Page/Page column 6, (2012/01/14)
The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for the
Fragment growing induces conformational changes in acetylcholine-binding protein: A structural and thermodynamic analysis
Edink, Ewald,Rucktooa, Prakash,Retra, Kim,Akdemir, Atilla,Nahar, Tariq,Zuiderveld, Obbe,Van Elk, Rene,Janssen, Elwin,Van Nierop, Pim,Van Muijlwijk-Koezen, Jacqueline,Smit, August B.,Sixma, Titia K.,Leurs, Rob,De Esch, Iwan J. P.
supporting information; experimental part, p. 5363 - 5371 (2011/06/11)
Optimization of fragment hits toward high-affinity lead compounds is a crucial aspect of fragment-based drug discovery (FBDD). In the current study, we have successfully optimized a fragment by growing into a ligand-inducible subpocket of the binding site
