191480-61-2 Usage
Description
1S,2S-N,N'-bis(phenylMethyl)-1,2-CyclohexanediaMine is a chiral diamine chemical compound with the molecular formula C20H26N2. It features a 1,2-cyclohexanediamine backbone to which two phenylmethyl groups are attached. 1S,2S-N,N'-bis(phenylMethyl)-1,2-CyclohexanediaMine is known for its use as a chiral ligand in asymmetric synthesis reactions and has demonstrated biological activity as an anti-inflammatory and anti-cancer agent. Its chiral nature and versatile reactivity make it a promising candidate for applications in organic synthesis, pharmaceuticals, and materials science. When handling and using 1S,2S-N,N'-bis(phenylMethyl)-1,2-CyclohexanediaMine, it is important to consult safety and regulatory information.
Uses
Used in Organic Synthesis:
1S,2S-N,N'-bis(phenylMethyl)-1,2-CyclohexanediaMine is used as a chiral ligand for facilitating asymmetric synthesis reactions. Its unique structure allows for the selective formation of enantiomerically pure compounds, which is crucial in the production of pharmaceuticals and agrochemicals where stereochemistry plays a significant role in biological activity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1S,2S-N,N'-bis(phenylMethyl)-1,2-CyclohexanediaMine is utilized as a chiral building block for the development of new drugs. Its ability to induce selectivity in chemical reactions can lead to the creation of more effective and safer medications with fewer side effects.
Used in Materials Science:
1S,2S-N,N'-bis(phenylMethyl)-1,2-CyclohexanediaMine is employed in materials science for the design and synthesis of novel chiral materials. These materials have potential applications in various fields, including sensors, catalysts, and optoelectronic devices, where chirality can impart unique properties.
Used as an Anti-inflammatory Agent:
1S,2S-N,N'-bis(phenylMethyl)-1,2-CyclohexanediaMine has been found to exhibit anti-inflammatory properties, making it a potential candidate for the development of new treatments for inflammatory diseases such as arthritis, asthma, and inflammatory bowel disease.
Used as an Anti-cancer Agent:
1S,2S-N,N'-bis(phenylMethyl)-1,2-CyclohexanediaMine has demonstrated biological activity as an anti-cancer agent, suggesting its potential use in the development of new cancer therapies. Further research is needed to explore its mechanism of action and efficacy in treating various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 191480-61-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,4,8 and 0 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 191480-61:
(8*1)+(7*9)+(6*1)+(5*4)+(4*8)+(3*0)+(2*6)+(1*1)=142
142 % 10 = 2
So 191480-61-2 is a valid CAS Registry Number.
191480-61-2Relevant articles and documents
Machine-Assisted Preparation of a Chiral Diamine Ligand Library and In Silico Screening Using Ab Initio Structural Parameters for Heterogeneous Chiral Catalysts
Kobayashi, Shū,Kuremoto, Tatsuya,Sadatsune, Ren,Yamashita, Yasuhiro,Yasukawa, Tomohiro
supporting information, p. 4204 - 4208 (2021/08/09)
A ligand library containing 31 chiral diamines was synthesized using a flow-based semiautomatic reductive amination system. These ligands were evaluated in a continuous-flow asymmetric 1,4-addition reaction with a heterogeneous Ni catalyst. Based on the experimental results of ab initio DFT calculations, a prediction model for enantioselectivities was successfully constructed. Furthermore, virtual screening of possible ligands was conducted to identify promising structures, which showed good enantioselectivities in experiments. (Figure presented.).
METAL CHELATORS FOR IMAGING, THERAPEUTICS, AND BIOANALYSIS
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Paragraph 0160, (2018/09/26)
A variety of compounds are provided capable of chelating a metal, in particular a lanthanide such as Eu(III) and Tb(III). Luminescent complexes of the compound and a metal ion are also provided, in particular luminescent metal complexes are provided containing a lanthanide such as Eu(III) or Tb(III) and a compound described herein. In some aspects, the luminescent complexes are capable of exhibiting bright emissions with high quantum yields. Methods of making the compound are provided. Methods of using the compounds and luminescent complexes are also provided, for example for imaging and therapeutic applications.
Efficient route to pre-organized and linear polyaminopolycarboxylates: Cy-TTHA, Cy-DTPA and mono/di- reactive, tert-butyl protected TTHA/Cy-TTHA
Mohamadi, Ali,Miller, Lawrence W.
, p. 1441 - 1444 (2017/03/23)
Pre-organized polyaminopolycarboxylate chelators Cy-TTHA and Cy-DTPA were synthesized via modular five-step syntheses from commercially available starting materials in ～62% and 47% overall yields, respectively. Furthermore, strategies are reported for the efficient preparation of mono- and di-reactive, tert-butyl-protected TTHA/Cy-TTHA to selectively functionalize central chelators’ carboxylic acids.
