19156-56-0

Basic information

• Product Name: 2,3-Dihydrobenzothiophene-3-carboxylic acid
• CAS NO: 19156-56-0
• Molecular Weight: 180.227
• Mol File: 19156-56-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-Dihydrobenzothiophene-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydrobenzothiophene-3-carboxylic acid(19156-56-0)
• EPA Substance Registry System: 2,3-Dihydrobenzothiophene-3-carboxylic acid(19156-56-0)

Safety Data

• Hazardous Substances Data: 19156-56-0(Hazardous Substances Data)

Usage

General Description

2,3-Dihydrobenzothiophene-3-carboxylic acid is a heterocyclic organic compound with a chemical structure that consists of a benzene ring fused to a thiophene ring, with a carboxylic acid group attached at the 3-position of the thiophene ring. 2,3-Dihydrobenzothiophene-3-carboxylic acid is used as a building block in the synthesis of various pharmaceutical and agrochemical products, due to its unique structural features and reactivity. It has been studied for its potential applications as an anti-inflammatory and analgesic agent, as well as a precursor for the synthesis of other bioactive compounds. Additionally, it has been investigated for its potential use in the field of materials science, particularly in the development of advanced polymers and organic electronic materials.

Upstream product

• 5381-25-9 benzo[b]thiophene-3-carboxylic acid 

Relevant articles and documents

Further structure-activity relationships in the series of tropanyl esters endowed with potent antinociceptive activity

Several analogs of the α-tropanyl esters of 2-(4-chlorophenoxy)butyric acid (SM21) and 2-phenylthiobutyric acid (SM32), endowed with potent antinociceptive and cognition enhancing activity, were synthesized, aimed at obtaining more potent and safe drug candidates. Variation of the acyl moiety, as well as the conformational restriction of atropine to give the α-tropanyl ester of 2,3-dihydrobenzofurane-3-carboxylic acid (18), practically abolished activity. In the case of 18, the antimuscarinic activity was also severely affected by the conformation restrain. On the contrary, conformational restriction of phenoxybutyric and phenylthiobutyric acid derivatives to give the α-tropanyl ester of 2,3-dihydro-benzofurane-2-carboxylic acid and 2,3-dihydro-benzothiophene-2-carboxylic acid, afforded potent analgesic drugs that unfortunately were too toxic to be reliable drug candidates. A series of related esters of benzofurane-3-carboxylic acid and benzothiophene-3-carboxylic acid were also studied and found to be potent but toxic analgesics.