19157-85-8Relevant articles and documents
An efficient synthesis of 4-chromanones
Zhong, Yong-Li,Boruta, David T.,Gauthier Jr., Donald R.,Askin, David
supporting information; experimental part, p. 4824 - 4826 (2011/10/04)
A two step efficient and practical synthesis of a variety of 4-chromanones is described. Phenols undergo a Michael addition to acrylonitriles in the presence of catalytic amounts of potassium carbonate and tert-butanol to generate the corresponding 3-aryloxypropanenitriles in 50-93% yields. Treatment of the resulting aryloxypropionitriles with 1.5 equiv of TfOH and 5 equiv of TFA, followed by an aqueous work up afforded 4-chromanones in moderate to excellent yields.