191599-51-6

Basic information

• Product Name: 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI)
• Synonyms: 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI);1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)-;(S)-(+)-N-Boc-nipecotic acid ethyl ester, Ethyl (3S)-1-tert-butoxycarbonyl-3-piperidinecarboxylate, (S)-1-(tert-Butyl) 3-ethyl 1,3-piperidinedicarboxylate, (S)-1-(tert-Butoxycarbonyl)-piperidine-3-carboxylic acid ethyl ester;(S)-1,3-Piperidinedicarboxylic acid 1-tert-butyl 3-ethyl ester;Ethyl (S)-N-Boc-piperidine-3-carboxylate;(S)-1-tert-butyl 3-ethyl piperidine-1,3-dicarboxylate;Ethyl N-Boc-L-nipecotate, 95%;(S)-Ethyl N-Boc-piperidine-3-carboxylate
• CAS NO: 191599-51-6
• Molecular Formula: C₁₃H₂₃NO₄
• Molecular Weight: 257.33
• Mol File: 191599-51-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 35-40 °C
• Boiling Point: 323.885 °C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.078 g/cm³
• Vapor Pressure: 0.000254mmHg at 25°C
• Refractive Index: 1.473
• CAS DataBase Reference: 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI)(191599-51-6)
• EPA Substance Registry System: 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI)(191599-51-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-26
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 191599-51-6(Hazardous Substances Data)

Usage

General Description

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI) is a chemical compound that belongs to the class of piperidine carboxylic acid esters. It is a chiral compound with a three-dimensional structure. 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI) has potential applications in the pharmaceutical industry due to its medicinal properties. It may be used as a building block in the synthesis of various drugs and can also serve as a starting material for the preparation of other chemical compounds. Additionally, it may have potential biological activity that can be explored for various applications.

InChI:InChI=1/C13H23NO4/c1-5-17-11(15)10-7-6-8-14(9-10)12(16)18-13(2,3)4/h10H,5-9H2,1-4H3/t10-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 37675-18-6 (S)-(+)-nipecotic acid ethyl ester 
• 498-95-3 (S)-nipecotic acid 

Downstream Products

• 88495-54-9 (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 1008563-07-2 (S)-3-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 384830-03-9 (2S,3R)-4-Oxo-3-(R)-1-piperidin-3-ylmethyl-azetidine-2-carboxylic acid benzyl ester 
• 384830-02-8 (R)-3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 384830-05-1 (2S,3R)-3-((R)-1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 
• 384830-06-2 (2S,3R)-3-((R)-1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-ylmethyl)-4-oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-1-carbonyl]-azetidine-2-carboxylic acid benzyl ester 
• 37675-19-7 (S)-piperidine-3-carboxylic acid ethyl ester hydrochloride 
• 278789-43-8 ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate 
• 191092-08-7 tert-butyl (3S)-3-[[(4-methylbenzenesulfonyl)oxy]methyl]piperidine-1-carboxylate 
• 140645-22-3 (3S)-3-azidomethyl-1-(tert-butoxycarbonyl)-piperidine 
• 140645-23-4 1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate 
• 6874-86-8 (–)-castoramine 
• 1008563-08-3 (S)-3-[1-(2-formyl-phenoxy)-1-methyl-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

One-Pot Reductive Allylation of Amides by Using a Combination of Titanium Hydride and an Allylzinc Reagent: Application to a Total Synthesis of (-)-Castoramine

A one-pot direct reductive allylation protocol has been developed for the synthesis of secondary amines by using titanium hydride and an allylzinc reagent. This protocol is applicable to a broad range of substrates, including acyclic amides, benzamides, α,β-unsaturated amides, and lactams. The stereochemical outcome obtained from the reaction with crotylzinc reagent suggested that the allylation reaction proceeds through a six-membered cyclic transition state. A total synthesis of (-)-castoramine was accomplished by following this protocol for the highly stereoselective construction of contiguous stereocenters.

NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF

The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.

4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure-activity relationships

Single enantiomer [(aryloxy)(pyridinyl)methyl]piperidine and pyrrolidine derivatives 5-9 are inhibitors of monoamine reuptake. Structure-activity relationships established that monoamine reuptake inhibition are functions of amine, pyridine isomer, aryloxy ring substitution and stereochemistry. Consequently, selective NRIs, selective SRIs, dual SNRIs and triple SNDRIs were all identified. Dual SNRIs 5l-a and 9c were evaluated in additional pharmacology and pharmacokinetic studies as representative examples from this series.