191739-36-3

Basic information

• Product Name: 1,2,4-Piperazinetricarboxylic acid, 1,4-bis(phenylmethyl) ester
• CAS NO: 191739-36-3
• Molecular Formula: C21H22N2O6
• Molecular Weight: 398.415
• Mol File: 191739-36-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1,2,4-Piperazinetricarboxylic acid, 1,4-bis(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Piperazinetricarboxylic acid, 1,4-bis(phenylmethyl) ester(191739-36-3)
• EPA Substance Registry System: 1,2,4-Piperazinetricarboxylic acid, 1,4-bis(phenylmethyl) ester(191739-36-3)

Safety Data

• Hazardous Substances Data: 191739-36-3(Hazardous Substances Data)

Usage

Common use

Reagent in organic synthesis and pharmaceutical research

Potential medicinal properties

a. Anti-inflammatory effects
b. Analgesic effects

Investigated for treatment of

a. Cancer
b. Neurodegenerative disorders

Potential application

Corrosion inhibitor in industrial processes

Interest to researchers and professionals

Various scientific and industrial applications

Upstream product

• 2762-32-5 piperazine-2-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 98-97-5 2-pyrazylcarboxylic acid 
• 3022-15-9 piperazine-2-carboxylic acid dihydrochloride 

Downstream Products

• 385765-07-1 C₄₁H₃₈N₄O₉ 
• 191739-39-6 benzyl 3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate 
• 161894-56-0 dibenzyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 

Relevant articles and documents

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

An orthogonal protection strategy for the synthesis of 2-substituted piperazines

Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-ones are readily prepared from the bis-carbamate protected piperazine-2-carboxylic acids and serve as orthogonally protected piperazines from which a variety of 2-substituted piperazines can be prepared. Sodium benzylate and sodium phenoxides react at the C-5 carbon of the oxazolidinone to yield 2-(benzyloxymethyl)piperazines and 2-(phenoxymethyl)piperazines, respectively. The tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-ones also provide convenient scaffolds from which 2-benzyl- and 2-phenethylpiperazines are prepared.

BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS

Compounds of formula (I) are useful in the treatment of vanilloid-receptor-meditated diseases, such as inflammatory or neuropathic pain and diseases involving sensory nerve function such as asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis.