191803-52-8

Basic information

• Product Name: (R)-CTH-JAFAPHOS
• Synonyms: (R)-(+)-1,1'-BIS(DIPHENYLPHOSPHINO)-2,2'-BIS(N,N-DI-I-PROPYLAMINO)FERROCENE;(R)-(+)-1,1'-BIS(DIPHENYLPHOSPHINO)-2,2'-BIS(N,N-DIISOPROPYLAMIDO)FERROCENE;(R)-CTH-JAFAPHOS;(R)-(+)-1,1'-Bis(diphenylphosphino)-2,2'-bis(N,N-diisopropylamido)ferrocene, (R)-CTH-JAFAPhos, 90%
• CAS NO: 191803-52-8
• Molecular Formula: C₄₈H₅₄FeN₂O₂P₂
• Molecular Weight: 752.73
• Mol File: 191803-52-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 206℃
• Appearance: /
• CAS DataBase Reference: (R)-CTH-JAFAPHOS(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-CTH-JAFAPHOS(191803-52-8)
• EPA Substance Registry System: (R)-CTH-JAFAPHOS(191803-52-8)

Safety Data

• Hazardous Substances Data: 191803-52-8(Hazardous Substances Data)

Usage

Description

(R)-CTH-JAFAPHOS is a chiral bisphosphine ligand that is widely utilized in asymmetric catalysis for the synthesis of various organic compounds with high enantioselectivity. This chemical is known for its excellent stability and activity, even in the presence of air and moisture, making it a popular choice for a broad spectrum of catalytic reactions. Its unique structure and properties allow it to effectively control the stereochemistry of the resulting products, which is highly valuable for the pharmaceutical and fine chemical industries. Furthermore, (R)-CTH-JAFAPHOS has been employed in the development of efficient and sustainable synthetic methodologies, showcasing its versatility and potential impact on the field of organic synthesis.

Uses

Used in Pharmaceutical Industry:
(R)-CTH-JAFAPHOS is used as a chiral ligand for asymmetric catalysis to synthesize various organic compounds with high enantioselectivity. This is crucial in the pharmaceutical industry as it helps in the production of enantiomerically pure drugs, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Fine Chemical Industry:
(R)-CTH-JAFAPHOS is used as a chiral ligand in asymmetric catalysis for synthesizing high enantioselective fine chemicals. These chemicals are vital in various applications, including fragrances, agrochemicals, and specialty materials, where the stereochemistry of the molecules plays a critical role in determining their properties and performance.
Used in Development of Sustainable Synthetic Methodologies:
(R)-CTH-JAFAPHOS is used as a key component in the development of efficient and sustainable synthetic methodologies. Its unique properties and versatility enable the creation of new, environmentally friendly, and cost-effective processes for the synthesis of complex organic molecules, which is essential for advancing the field of organic synthesis and meeting the growing demand for sustainable chemical production.

Upstream product

• 107139-36-6 1,1'-N,N,N',N'-tetraisopropylferrocenedicarboxamide 
• 1079-66-9 chloro-diphenylphosphine 

Relevant articles and documents

(-)-Sparteine-mediated stereoselective directed ortho metalation of ferrocene diamides

The utility of (-)-sparteine-mediated directed ortho metalation (DoM) has been investigated in stereoselective preparation of planar chiral ferrocenes derived from 1,1′-N,N,N′,N′- tetraisopropylferrocenedicarboxamide (5). In the synthesis of C 2-symmetric analogs of 5, the protocol (base, solvent, and two-step DoM) was found to be crucial for obtaining high enantio- and diastereo-selectivities of the products. A variety of highly enantioenriched mono and doubly functionalized derivatives of 5 have been synthesized. The synthetic applications of these compounds as chiral ligands in asymmetric alkylation of aldehydes and asymmetric palladium-catalyzed allylic substitutions have been demonstrated.