191873-51-5

Basic information

• Product Name: 4-(2-Iodo-6-methoxy-phenoxymethyl)-1-methyl-1,2,3,6-tetrahydro-pyridine
• Synonyms: 4-(2-Iodo-6-methoxy-phenoxymethyl)-1-methyl-1,2,3,6-tetrahydro-pyridine
• CAS NO: 191873-51-5
• Molecular Weight: 359.207
• Mol File: 191873-51-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-Iodo-6-methoxy-phenoxymethyl)-1-methyl-1,2,3,6-tetrahydro-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Iodo-6-methoxy-phenoxymethyl)-1-methyl-1,2,3,6-tetrahydro-pyridine(191873-51-5)
• EPA Substance Registry System: 4-(2-Iodo-6-methoxy-phenoxymethyl)-1-methyl-1,2,3,6-tetrahydro-pyridine(191873-51-5)

Safety Data

• Hazardous Substances Data: 191873-51-5(Hazardous Substances Data)

Upstream product

• 111726-46-6 2-iodo-6-methoxyphenol 
• 73220-26-5 1-methoxy-2-(methoxymethoxy)benzene 
• 10445-91-7 4-(Chloromethyl)pyridine 
• 191873-50-4 4-(2-Iodo-6-methoxy-phenoxymethyl)-pyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 191873-52-6 4-(2-Iodo-6-methoxy-phenoxymethyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of morphine fragments spiro[benzofuran-3(2H),4'-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinoline by intramolecular heck reaction

As a better alternative to radical cyclization, 5-(2-bromo-6-methoxyphenoxy)-2-methyl-1 ,2,3,4,5,6,7,8-octahydroisoquinoline (2) and its 1-oxo analog 3 underwent Pd-catalyzed intramolecular cyclization to give the tetracyclic (ACNO) morphine fragments 5 and 6 respectively. 4-[(2'-Iodo-6'-methoxyphenoxy)methyl]-1-ethoxycarbonyl-1,2,5,6, -tetrahydropyridine (11) reacted similarly to provide the tricyclic ANO fragment 12 in 70% yield and 45% e.e. when a Pd-(S)-BINAP complex was used as the catalyst.