191939-66-9

Basic information

• Product Name: cyclohexyl 3(S)-3-(tritylamino)-4-oxo-6-isopropyloct-7-enoate
• CAS NO: 191939-66-9
• Molecular Weight: 509.689
• Mol File: 191939-66-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: cyclohexyl 3(S)-3-(tritylamino)-4-oxo-6-isopropyloct-7-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: cyclohexyl 3(S)-3-(tritylamino)-4-oxo-6-isopropyloct-7-enoate(191939-66-9)
• EPA Substance Registry System: cyclohexyl 3(S)-3-(tritylamino)-4-oxo-6-isopropyloct-7-enoate(191939-66-9)

Safety Data

• Hazardous Substances Data: 191939-66-9(Hazardous Substances Data)

Upstream product

• 151036-42-9 N^α-trityl-L-aspartic acid β-cyclohexyl ester 
• 112259-66-2 β-cyclohexyl L-aspartate 
• 73821-95-1 Boc-Asp(O-cyclohexyl)-OH 
• 31950-55-7 4-Bromo-3-methyl-1-butene 
• 151012-00-9 N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester 

Downstream Products

• 191939-68-1 cyclohexyl 3-[(tert-butyloxycarbonyl)amino]-4-oxo-6-methyl-7-octenoate 

Relevant articles and documents

Stabilized analogs of thymopentin. 2. 1,2- and 3,4-ketomethylene pseudopeptides

In this second paper in a series of three studies of stable analogs of thymopentin (Arg1-Lys2-Asp3-Val4-Tyr5), the synthesis of analogs stablized at peptide bonds 1,2 and 3,4 via insertion of ketomethylene units is described. A tris(carbobenzyloxy)arginyl(k)norleucine pseudopeptide was synthesized and coupled to Asp-Val-Phe-resin units followed by HF cleavage to prepare Arg(k)Nle-Asp-Val-Phe analogs. Preparation of N-BOC Asp(k)Val and N- BOC Asp(k)Ala units followed by coupling to Phe- or Tyr-resin units provided resin-bound pseudotripeptide substrates for attachment of various arginyl dipeptides. Cleavage from the resin afforded 3,4-ketomethylene-stabilized pseudopeptide analogs of thymopentin. The Arg-Lys-Asp(k)Val-Phe and ArgLys- Asp(k)Val-Tyr analogs were more strongly bound to CEM cells than thymopentin itself. There was significant enhancement of stability in serum for the analogs, especially those containing Arg(k)Nle or Arg-NMeLys moieties at the 1,2-peptide bond.