19202-04-1

Basic information

• Product Name: (4-Chlorophenyl)(morpholino)methanone
• Synonyms: (4-Chlorophenyl)(morpholino)methanone;4-(morpholinocarbonyl)chlorobenzene;N-(4-Chlorobenzoyl)morpholine
• CAS NO: 19202-04-1
• Molecular Formula: C₁₁H₁₂ClNO₂
• Molecular Weight: 225.67
• Product Categories: blocks;Carboxes
• Mol File: 19202-04-1.mol
• Article Data: 76

Chemical Properties

• Melting Point: 76 °C
• Boiling Point: 382.4°Cat760mmHg
• Flash Point: 185°C
• Appearance: /
• Density: 1.271g/cm³
• Vapor Pressure: 4.75E-06mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• PKA: -1.73±0.20(Predicted)
• CAS DataBase Reference: (4-Chlorophenyl)(morpholino)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Chlorophenyl)(morpholino)methanone(19202-04-1)
• EPA Substance Registry System: (4-Chlorophenyl)(morpholino)methanone(19202-04-1)

Safety Data

• Hazardous Substances Data: 19202-04-1(Hazardous Substances Data)

Usage

General Description

(4-Chlorophenyl)(morpholino)methanone is a chemical compound with the molecular formula C11H12ClNO2. It is a white to off-white solid and is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. (4-Chlorophenyl)(morpholino)methanone has a morpholine ring attached to a phenyl group with a chlorine atom and a ketone functional group. It is not suitable for human consumption and should be handled with care due to its potential to cause skin and eye irritation. Additionally, it should be stored in a cool, dry place away from direct sunlight and heat sources. Overall, this chemical compound is commonly used as a building block in organic synthesis for various industrial applications.

InChI:InChI=1/C11H12ClNO2/c12-10-3-1-9(2-4-10)11(14)13-5-7-15-8-6-13/h1-4H,5-8H2

Upstream product

• 21011-44-9 4-(4-chloro-thiobenzoyl)-morpholine 
• 2227-79-4 benzenecarbothioamide 
• 110-91-8 morpholine 
• 32792-54-4 2,4-dinitrophenyl 4-chlorobenzoate 
• 6264-29-5 4-nitrophenyl 4-chlorobenzoate 
• 24252-90-2 S-(p-nitrophenyl) p-chlorothiobenzoate 
• 122-01-0 4-chloro-benzoyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 74-11-3 para-chlorobenzoic acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 106-39-8 bromochlorobenzene 
• 68388-09-0 4-chlorobenzoic acid N-hydroxysuccinimide ester 

Downstream Products

• 13169-71-6 2-(4-chlorobenzoyl)pyrrole 
• 63833-36-3 5-(4-chloro-benzoyl)-2,4-dimethyl-pyrrole-3-carboxylic acid ethyl ester 
• 889130-18-1 (4-chlorophenyl)(dimethyl(phenyl)silyl)methanone 
• 154047-16-2 (4-Chloro-phenyl)-(1H-pyrrol-2-yl)-methanol 
• 154047-00-4 (1-Allyl-1H-pyrrol-2-yl)-(4-chloro-phenyl)-methanone 
• 154047-19-5 (1-Allyl-1H-pyrrol-2-yl)-(4-chloro-phenyl)-methanol 
• 389621-84-5 4-(morpholine-4-carbonyl)phenylboronic acid 
• 1450995-69-3 (2R,3S)-4-benzyl-2-[hydroxy-(4-chlorophenyl)methyl]-morpholin-3-one 

Relevant articles and documents

NaI-mediated oxidative amidation of benzyl alcohols/aromatic aldehydes to benzamides via electrochemical reaction

In this research, we have developed a mild electrochemical process for oxidative amidation of benzyl alcohols/aromatic aldehydes with cyclic amines into the corresponding benzamides. This electroorganic synthetic method proceeds using NaI as a redox mediator under ambient temperature in undivided cell, providing more than 25 examples of amide products in moderate to good yields. The benefits of this reaction include one-pot synthesis, open air condition, proceed in aqueous media and no requirement of external conducting salt, base and oxidant.

Direct Amidation of Esters by Ball Milling**

The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.

Pd(triNHC)-catalyzed Double Carbonylation of Aryliodides With Amines: The Effect of triNHC Ligands

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