19230-45-6

Basic information

• Product Name: N-(3-iodophenyl)acetamide
• CAS NO: 19230-45-6
• Molecular Formula: C₈H₈INO
• Molecular Weight: 261.062
• Mol File: 19230-45-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 376.2°Cat760mmHg
• Flash Point: 181.3°C
• Density: 1.805g/cm³
• CAS DataBase Reference: N-(3-iodophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-iodophenyl)acetamide(19230-45-6)
• EPA Substance Registry System: N-(3-iodophenyl)acetamide(19230-45-6)

Safety Data

• Hazardous Substances Data: 19230-45-6(Hazardous Substances Data)

Usage

General Description

N-(3-iodophenyl)acetamide is a chemical compound with the molecular formula C8H8INO. It is an organic compound and an acetamide derivative that contains a phenyl group substituted with an iodine atom. This chemical is often used in the synthesis of pharmaceutical compounds and as an intermediate in organic synthesis. It is also used in the preparation of other chemical compounds and has been studied for its potential biological activities. N-(3-iodophenyl)acetamide is a white to off-white crystalline solid that is slightly soluble in water and soluble in organic solvents. It should be handled and used with proper precautions as it can be harmful if ingested, inhaled, or in contact with skin and eyes.

Upstream product

• 75-05-8 acetonitrile 
• 78887-39-5 3-Acetamidophenylboronic acid 
• 762-72-1 allyl-trimethyl-silane 
• 645-00-1 m-iodonitrobenzene 
• 75-36-5 acetyl chloride 
• 626-01-7 3-Iodoaniline 
• 108-24-7 acetic anhydride 
• 457658-05-8 N-meta-iodophenyl urea 

Downstream Products

• 110179-19-6 (3-acetylamino-phenyl)-phenyl-iodonium ; iodide 
• 104581-39-7 N-{3-[1-(3-Acetylamino-phenyl)-3-hydroxy-3-methyl-but-1-enyl]-phenyl}-acetamide 
• 93298-23-8 N-{3-[1-(3-Acetylamino-phenyl)-3-oxo-butyl]-phenyl}-acetamide 
• 104581-30-8 2-methyl-4-(3-acetylaminophenyl)-3-butyn-2-ol 
• 19260-01-6 C₈H₇IN₂O₂ 
• 860218-60-6 acetic acid-(3-iodosyl-anilide) 
• 93298-15-8 N-[3-((E)-3-Oxo-pent-1-enyl)-phenyl]-acetamide 
• 93298-26-1 N-{3-[1-(3-Acetylamino-phenyl)-3-oxo-pentyl]-phenyl}-acetamide 
• 133570-33-9 N-[3-(5-Hydroxy-tetrahydro-furan-3-yl)-phenyl]-acetamide 
• 116008-50-5 acetic acid-(3-dichloroiodanyl-anilide) 
• 7463-31-2 3-Acetamidoacetophenone 

Relevant articles and documents

Z-Selective Fluoroalkenylation of (Hetero)Aromatic Systems by Iodonium Reagents in Palladium-Catalyzed Directed C?H Activation

The direct and catalytic incorporation of fluorine containing molecular motifs into organic compounds resulting high-value added chemicals represents a rapidly evolving part of synthetic methodologies, thus this area is in the focus of pharmaceutical and agrochemical research. Herein we report a stereoselective procedure for direct fluorovinylation of aromatic and heteroaromatic scaffolds. This methodology development has been realized by palladium-catalyzed ortho C?H activation reaction of aniline derivatives featuring the regioselectivity via directing groups such as secondary of tertiary amides, ureas or ketones. The application of non-symmetrical aryl(fluoroalkenyl)-iodonium salts as fluoroalkenylating agents allowed mild reaction conditions in general for this transformation. The scope and limitations have been thoroughly investigated and the feasibility has been demonstrated by more than 50 examples.

NEAR-INFRARED NERVE-SPARING BENZO[C]PHENOXAZINE FLUOROPHORES

Provided are near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.

Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.