192431-42-8Relevant articles and documents
Total synthesis of (-)-strychnine via the Wieland - Gumlich aldehyde
Sole, Daniel,Bonjoch, Josep,Garcia-Rubio, Silvina,Peidro, Emma,Bosch, Joan
, p. 395 - 397 (1999)
Fifteen steps suffice for an enantioselective total synthesis of (-)- strychnine (1) from 1,3-cyclohexanedione. The key steps are the easy generation of the enantiopure intermediate 2, the closure of the piperidine ring by a reductive Heck reaction, and the elaboration of the indoline nucleus in an advanced synthetic stage. TBDMS = tert-butyldimethylsilyl.