19250-17-0Relevant articles and documents
Synthesis and Bioactivity of N-(4-(N′-Substituted Sulfamoyl)Phenyl)Myrtenamides Containing a Heterocycle
Lin, Guishan,Duan, Wengui,Liu, Hongqiang,Ma, Yuan,Lei, Fuhou
, p. 56 - 62 (2018)
A series of N-(4-(N′-substituted sulfamoyl)phenyl)myrtenamides containing a heterocycle were designed and synthesized by a multiple-step procedure using α-pinene as starting material. All the synthesized compounds were characterized and analyzed by GC, HPLC, UV-vis, FTIR, NMR, GC-MS, and ESI-MS. The preliminary bioassay showed that, at 50 μg/mL, the target compounds exhibited a certain antifungal activity against the five tested fungi, in which compound 5f exhibited antifungal activity of 83.2% and 70.0% against Physalospora piricola and Alternaria solani, respectively. Moreover, compound 5d displayed herbicidal activity of 86.0% against the root of rape (Brassica campestris) at 100 μg/mL.
Synthesis method of myrtenyl dihydrazide compound with fungal inhibition activity
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Paragraph 0046; 0051-0052, (2021/07/17)
A synthesis method of a myrtenyl dihydrazide compound with fungal inhibition activity comprises the following steps of: firstly, selectively oxidizing alpha-pinene into myrtenyl, further oxidizing the myrtenyl into myrtenic acid, then reacting the myrtenic acid with thionyl chloride to obtain myrtenic acid acyl chloride, and finally, carrying out hydrazinolysis reaction with a series of substituted benzoyl hydrazine or 2-pyridine formyl hydrazine under an anhydrous condition, and synthesizing to obtain the myrtenyl dihydrazide compound. A bacteriostatic activity test shows that the myrtenyl dihydrazide compound has excellent broad-spectrum inhibitory activity on various plant pathogenic fungi, and can be used as a lead compound of a novel agricultural bactericide.
