192508-36-4

Basic information

• Product Name: (4-FLUORO-3-NITROPHENYL)ACETIC ACID
• Synonyms: (4-FLUORO-3-NITROPHENYL)ACETIC ACID;3-nitro-4-fluorophenylacetic acid;2-(4-Fluoro-3-nitrophenyl)acetic acid;2-(4-Fluoro-3-nitrophenyl)
• CAS NO: 192508-36-4
• Molecular Formula: C₈H₆FNO₄
• Molecular Weight: 199.14
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;Fluorine series
• Mol File: 192508-36-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 391.209°C at 760 mmHg
• Flash Point: 190.397°C
• Appearance: /
• Density: 1.498g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: (4-FLUORO-3-NITROPHENYL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-3-NITROPHENYL)ACETIC ACID(192508-36-4)
• EPA Substance Registry System: (4-FLUORO-3-NITROPHENYL)ACETIC ACID(192508-36-4)

Safety Data

• Hazardous Substances Data: 192508-36-4(Hazardous Substances Data)

Usage

General Description

(4-Fluoro-3-nitrophenyl)acetic acid is a chemical compound with the molecular formula C8H6FNO4. It is a derivative of phenylacetic acid, with a fluorine atom and a nitro group attached to the phenyl ring. (4-FLUORO-3-NITROPHENYL)ACETIC ACID is used in pharmaceutical research and drug development, as it has potential pharmacological properties. It may be utilized as an intermediate in the synthesis of various biologically active compounds, including pharmaceuticals and agrochemicals. Additionally, it has been studied for its potential anti-inflammatory and analgesic properties. The compound's chemical structure and properties make it a subject of interest for further exploration in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C8H6FNO4/c9-6-2-1-5(4-8(11)12)3-7(6)10(13)14/h1-3H,4H2,(H,11,12)

Upstream product

• 226888-37-5 4-fluoro-3-nitrophenylacetic acid methyl ester 
• 157662-77-6 2-(4-fluoro-3-nitrophenyl)acetonitrile 
• 405-50-5 p-Fluorophenylacetic acid 

Downstream Products

• 192508-37-5 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid methyl ester 
• 226888-23-9 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-isopropoxy-4-methoxybenzyl)-3-phenylpropionamide 
• 454186-13-1 2-(4-fluoro-3-nitro-phenyl)-N-methyl-acetamide 
• 454185-89-8 [2-(4-fluoro-3-nitro-phenyl)-ethyl]-methyl-carbamic acid ethyl ester 
• 454186-14-2 3-{4-[(S)-6,7-Dimethoxy-8-(6-methoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl]-phenoxy}-4-isopropoxy-benzoic acid methyl ester 
• 454185-87-6 3-[4-((S)-8-{4-[2-(Ethoxycarbonyl-methyl-amino)-ethyl]-2-methoxy-phenoxy}-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenoxy]-4-isopropoxy-benzoic acid methyl ester 
• 454186-06-2 8-{4-[2-(ethoxycarbonyl-methyl-amino)-ethyl]-2-nitro-phenoxy}-1-[4-(2-isopropoxy-5-methoxycarbonyl-phenoxy)-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 192508-38-6 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid 
• 192508-41-1 2-(4-fluoro-3-nitrophenyl)-N-<(3-hydroxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 
• 192508-40-0 2-(4-fluoro-3-nitrophenyl)-N-<(3-isopropoxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 
• 226888-40-0 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide 
• 226888-37-5 4-fluoro-3-nitrophenylacetic acid methyl ester 

Relevant articles and documents

MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE

Provided are IDO inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases such as chronic viral infection, chronic bacterial infections, cancer, sepsis or a neurological disorder.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

First enantioselective total synthesis of (-)-tejedine

(Matrix presented) The first enantioselective total synthesis of (-)-tejedine (1) is reported. Tejedine is a seco-bisbenzyltetrahydroisoquinoline isolated in 1998 as a minor component from Berberis vulgaris. The synthesis was achieved using a strategy employing four key steps, including a chiral auxiliary-assisted diastereoselective Bischler-Napieralski cyclization.