192570-28-8

Basic information

• Product Name: Benzoic acid, 2-[(aminocarbonyl)amino]-6-chloro-
• CAS NO: 192570-28-8
• Molecular Formula: C8H7ClN2O3
• Molecular Weight: 214.608
• Mol File: 192570-28-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(aminocarbonyl)amino]-6-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(aminocarbonyl)amino]-6-chloro-(192570-28-8)
• EPA Substance Registry System: Benzoic acid, 2-[(aminocarbonyl)amino]-6-chloro-(192570-28-8)

Safety Data

• Hazardous Substances Data: 192570-28-8(Hazardous Substances Data)

Upstream product

• 2148-56-3 2-chloro-6-aminobenzoic acid 
• 917-61-3 sodium isocyanate 

Downstream Products

• 192570-52-8 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-chloro-quinazoline-2,4(3H)-dione 
• 192570-57-3 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-5-chloro-quinazoline-2,4(3H)-dione 
• 78754-81-1 5-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 

Relevant articles and documents

Tripler stability of oligodeoxynucleotides containing substituted quinazoline-2,4-(1H,3H)-dione

Triple helical structures can be observed between double-stranded nucleic acids and a third strand through the formation of Hoogsteen hydrogen bond. We report here the use of quinazoline-2,4-dione derivatives as substitutes for thymine in TA*T triplets. The synthesis and the characterization of monochloro derivatives of quinazoline-2,4-dione as well as 5-fluoro and 6-nitro substituted quinazoline rings are described. The ability of the various modified bases to promote the formation of triplexes was reached by thermal denaturation studies.