192570-59-5

Basic information

• Product Name: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-7-chloro-quinazoline-2,4(3H)-dione
• CAS NO: 192570-59-5
• Molecular Weight: 615.082
• Mol File: 192570-59-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-7-chloro-quinazoline-2,4(3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-7-chloro-quinazoline-2,4(3H)-dione(192570-59-5)
• EPA Substance Registry System: 1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-7-chloro-quinazoline-2,4(3H)-dione(192570-59-5)

Safety Data

• Hazardous Substances Data: 192570-59-5(Hazardous Substances Data)

Upstream product

• 192570-39-1 1-(3,5-di-O-p-toluoyl-2-deoxy-α,β-D-erythro-pentofuranosyl)-7-chloro-quinazoline-2,4(3H)-dione 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 13165-35-0 7-chloroquinazoline-2,4-dione 

Relevant articles and documents

Tripler stability of oligodeoxynucleotides containing substituted quinazoline-2,4-(1H,3H)-dione

Triple helical structures can be observed between double-stranded nucleic acids and a third strand through the formation of Hoogsteen hydrogen bond. We report here the use of quinazoline-2,4-dione derivatives as substitutes for thymine in TA*T triplets. The synthesis and the characterization of monochloro derivatives of quinazoline-2,4-dione as well as 5-fluoro and 6-nitro substituted quinazoline rings are described. The ability of the various modified bases to promote the formation of triplexes was reached by thermal denaturation studies.