1926-72-3

Basic information

• Product Name: (+/-)-4-Hydroxynorephedrin
• Synonyms: (+/-)-4-Hydroxynorephedrin
• CAS NO: 1926-72-3
• Molecular Weight: 167.208
• Mol File: 1926-72-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (+/-)-4-Hydroxynorephedrin(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-4-Hydroxynorephedrin(1926-72-3)
• EPA Substance Registry System: (+/-)-4-Hydroxynorephedrin(1926-72-3)

Safety Data

• Hazardous Substances Data: 1926-72-3(Hazardous Substances Data)

Upstream product

• 635304-43-7 (2R)-1-[4-(benzyloxy)phenyl]-2-[((1R)-phenylethyl)amino]-1-propanone hydrobromide 
• 635304-39-1 (2S)-1-[4-(benzyloxy)phenyl]-2-[((1R)-phenylethyl)amino]-1-propanone methanesulfonate 
• 635304-65-3 (2S)-1-(4-hydroxyphenyl)-2-[((1R)-phenylethyl)amino]-1-propanone 
• 635304-44-8 (1R, 2S)-1-[4-(benzyloxy)phenyl]-2-[((1R)-phenylethyl)amino]-1-propanol 
• 103-49-1 dibenzylamine 
• 100-46-9 benzylamine 
• 25070-02-4 (1RS,2RS)-2-dibenzylamino-1-(4-benzyloxy-phenyl)-propan-1-ol 
• 104-88-1 4-chlorobenzaldehyde 
• 552-85-2 p-hydroxynorepherdine 
• 552-85-2 (+/-)-p-Hydroxy-norephedrin 

Downstream Products

• 395-28-8 (1RS,2RS)-1-(4-hydroxy-phenyl)-2-((Ξ)-β-phenoxy-isopropylamino)-propan-1-ol 
• 395-28-8 (+/-)-1-<4-Hydroxyphenyl>-2-<1-methyl-2-phenoxyaethylamino>-propan-1-ol 
• 395-28-8 (1RS,2SR)-1-(4-hydroxy-phenyl)-2-((RS)-β-phenoxy-isopropylamino)-propan-1-ol 
• 552-85-2 4-((1R,2S)-2-amino-1-hydroxypropyl)phenol 
• 255733-81-4 ethyl 2-(4-(2-((1R,2S)-1-(4-hydroxyphenyl)-1-hydroxyprop-2-ylamino)ethyl)-2,5-dimethylphenoxy)acetate 
• 247073-80-9 ethyl 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]-2-methylpropionate 

Relevant articles and documents

Method for synthesizing ritodrine hydrochloride

The invention discloses a method for synthesizing ritodrine hydrochloride. The method comprises that p-chlorobenzaldehyde and pyruvic acid as substrates undergo a catalytic reaction, the product is purified to form (R)-1-(4-chlorophenyl)-1-hydroxypropane-2-one, the (R)-1-(4-chlorophenyl)-1-hydroxypropane-2-one and ammonium formate as substrates undergo a catalytic reaction, the product is purifiedto form (1R, 2S)-2-amino-1-(4-chlorophenyl)-1-propanol, the (1R, 2S)-2-amino-1-(4-chlorophenyl)-1-propanol and LiOH. H2O undergo a reaction to produce 4-((1R, 2S)-2-amino-1-hydroxypropyl)phenol and 4-((1R, 2S)-2-amino-1-hydroxypropyl)phenol and 4-(2-chloroethanol)phenol undergo a reaction to produce ritodrine hydrochloride. The method realizes a low cost, utilizes mild reaction conditions and issuitable for industrial production.

PROCESS FOR PRODUCING OPTICALLY ACTIVE s-AMINO ALCOHOL

A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.

Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4- hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7-yl]carbamate

Metabolism studies with ethyl [5-amino-1,2-dihydro-2-methyl-3- phenylpyrido[3,4-b]pyrazin-7-yl]carbamate (1) in mice were reported previously to give a hydroxylated metabolite, which was methylated to give a methoxy derivative. The metabolite and its deri