192637-00-6

Basic information

• Product Name: 4-{(E)-2-[(R)-1-Ethoxycarbonyl-2-((E)-3-ethoxycarbonyl-allylsulfanyl)-ethylcarbamoyl]-propenyl}-benzoic acid
• Synonyms: 4-{(E)-2-[(R)-1-Ethoxycarbonyl-2-((E)-3-ethoxycarbonyl-allylsulfanyl)-ethylcarbamoyl]-propenyl}-benzoic acid
• CAS NO: 192637-00-6
• Molecular Weight: 449.525
• Mol File: 192637-00-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{(E)-2-[(R)-1-Ethoxycarbonyl-2-((E)-3-ethoxycarbonyl-allylsulfanyl)-ethylcarbamoyl]-propenyl}-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{(E)-2-[(R)-1-Ethoxycarbonyl-2-((E)-3-ethoxycarbonyl-allylsulfanyl)-ethylcarbamoyl]-propenyl}-benzoic acid(192637-00-6)
• EPA Substance Registry System: 4-{(E)-2-[(R)-1-Ethoxycarbonyl-2-((E)-3-ethoxycarbonyl-allylsulfanyl)-ethylcarbamoyl]-propenyl}-benzoic acid(192637-00-6)

Safety Data

• Hazardous Substances Data: 192637-00-6(Hazardous Substances Data)

Upstream product

• 192636-97-8 4-{(E)-2-[(R)-1-Ethoxycarbonyl-2-((E)-3-ethoxycarbonyl-allylsulfanyl)-ethylcarbamoyl]-propenyl}-benzoic acid tert-butyl ester 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 118143-52-5 N-Boc-L-cysteine ethyl ester 
• 159675-85-1 p-(t-butoxycarbonyl)-α-methylcinnamic acid 
• 192636-61-6 N-t-butoxycarbonyl-S-(3-ethoxycarbonyl-2-propenyl) cysteine ethyl ester 

Relevant articles and documents

New serine protease inhibitors with leukotriene B4 (LTB4) receptor binding affinity

A series of new trypsin-like serine protease inhibitors, 1, 2 and 7-23, containing amidinobenzene moiety was found to show potent LTB4-receptor affinity. Among them, compounds 1 and 2 were found to be LTB4 receptor antagonists based on an inhibition assay of human polymorphonuclear neutrophil (PMN) intracellular calcium mobilization induced by LTB4. Compounds 1 and 2, which satisfy the reported structural requirements for good oral activity, are expected to show a balanced dual mode of action, i.e., protease inhibitory activity and LTB4 receptor antagonist activity, in vivo.