192701-73-8

Basic information

• Product Name: METHYL 3-P-TOLYL-1H-PYRAZOLE-5-CARBOXYLATE
• Synonyms: METHYL 3-P-TOLYL-1H-PYRAZOLE-5-CARBOXYLATE;Methyl 5-(p-tolyl)-1H-pyrazole-3-carboxylate;methyl 3-(4-methylphenyl)-1H-pyrazole-5-carboxylate;-1H-pyrazole-5-carboxylate;Methyl 3-(p-tolyl)
• CAS NO: 192701-73-8
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.239
• Mol File: 192701-73-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 3-P-TOLYL-1H-PYRAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-P-TOLYL-1H-PYRAZOLE-5-CARBOXYLATE(192701-73-8)
• EPA Substance Registry System: METHYL 3-P-TOLYL-1H-PYRAZOLE-5-CARBOXYLATE(192701-73-8)

Safety Data

• Hazardous Substances Data: 192701-73-8(Hazardous Substances Data)

Usage

General Description

Methyl 3-p-tolyl-1H-pyrazole-5-carboxylate is an organic chemical compound known for its versatile applications in biochemistry, especially in the realm of pharmacology. It is a derivative of pyrazole, a heterocyclic aromatic organic compound that holds potential as a pharmacophore. This unique compound's attributes can aid in the creation of various beneficial drugs and can work as an inhibitor for certain biological processes. Its molecular formula is C12H12N2O2 and it falls under the category of aromatic heteromonocyclic compounds. Furthermore, it is essential to handle this chemical compound appropriately, adhering to safety guidelines, to prevent exposure risks.

Upstream product

• 67-56-1 methanol 
• 46413-67-6 5-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid 
• 39757-29-4 methyl 2,4-dioxo-4-p-tolylbutanoate 
• 1589523-24-9 methyl (E)-2-diazo-4-(p-tolyl)but-3-enoate 
• 127404-74-4 (E)-4-(4-tolyl)-3-butenoic acid 
• 1250907-64-2 methyl (E)-4-(p-tolyl)but-3-enoate 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 1029087-20-4 methyl 1-(tetrahydro-2H-pyran-2-yl)-5-p-tolyl-1H-pyrazole-3-carboxylate 
• 46413-67-6 5-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid 
• 1416981-55-9 C₃₃H₃₁N₃O₈ 
• 1375158-52-3 methyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-53-4 methyl 1-benzyl-5-(4-methylphenyl)-1H-pyrazole-3-carboxylate 
• 1375158-57-8 1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide 
• 1375158-58-9 1-benzyl-3-(4-methylphenyl)-N'-quinolin-2-yl-1H-pyrazole-5-carbohydrazide 
• 1375158-59-0 4-tert-butylphenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-60-3 4-(isopropyl)phenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-61-4 4-(heptyloxy)phenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-62-5 4-[4-(trifluoromethyl)phenoxy]phenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-63-6 4-(1H-imidazol-1-yl)phenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-64-7 ethyl 1-{[1-benzyl-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbonyl}piperidine-4-carboxylate 
• 1375158-65-8 1-{[1-benzyl-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbonyl}-4-(4-tert-butylbenzyl)piperazine 

Relevant articles and documents

Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles

Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95percent. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- A nd tri-substituted pyrazoles. With the ability to produce highly substituted pyrazoles and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold and may be of interest to all branches of the chemical industry.

Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents

A series of different heteroaromatic linked 4β-amidopodophyllotoxin conjugates (16a-i, 17a-i and 18a-d) were synthesized and evaluated for anticancer activity against five human cancer cell lines. Among the series, one of the compound 17g showed significant antiproliferative activity in A549 (lung cancer) cell line. Flow cytometric analysis showed that 17g arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggests that 17g induces cell death by apoptosis.