192726-04-8

Basic information

• Product Name: (S)-N-[(2S,4S,5S)-5-(Dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• Synonyms: (S)-N-[(2S,4S,5S)-5-(Dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide;(αS)-N-[(1S,3S,4S)-4-[Bis(phenylMethyl)aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)
• CAS NO: 192726-04-8
• Molecular Formula: C₄₁H₅₀N₄O₃
• Molecular Weight: 646.8607
• Product Categories: Aromatics Compounds;Aromatics;Chiral Reagents;Intermediates;Aromatics, Chiral Reagents, Intermediates
• Mol File: 192726-04-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-N-[(2S,4S,5S)-5-(Dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-[(2S,4S,5S)-5-(Dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide(192726-04-8)
• EPA Substance Registry System: (S)-N-[(2S,4S,5S)-5-(Dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide(192726-04-8)

Safety Data

• Hazardous Substances Data: 192726-04-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

(S)-N-[(2S,4S,5S)-5-(Dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide (cas# 192726-04-8) is a compound useful in organic synthesis.

Upstream product

• 192800-77-4 2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride 
• 156732-15-9 (2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane 
• 192725-50-1 (S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid 
• 402712-50-9 N-(2S-(2-oxotetrahydropyrimidin-1-yl)-3-methylbutanoyl)imidazole 
• 72-18-4 L-valine 
• 51078-49-0 N-(2-cyanoethyl)-L-valine 
• 192726-03-7 (S)-(-)-N-carboxymethyl-N(β)cyanoethyl valine 
• 1026752-79-3 N-(3-aminopropyl)-N-(methoxycarbonyl)-L-valine 

Downstream Products

• 192726-05-9 (2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(2-oxotetrahydropyrimidin-2-yl)-3-methylbutanoyl)amino-1,6-diphenylhexane 
• 192726-06-0 (2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt 
• 192725-17-0 lopinavir 

Relevant articles and documents

Synthesis and characterization of novel analogues of lopinavir

The present work describes the identification, origin, synthesis, characterization and control of four novel analogues of lopinavir viz. leucine analogue of lopinavir, isoleucine analogue of lopinavir, methyl analogue of lopinavir and dihydroxy analogue of lopinavir.

PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE (2S,3S,5S)-5-AMINO-2-N,N-DIBENZYLAMINO-3-HYDROXY-1,6-DIPHENYLHEXANE

The present invention relates to the purification of (2S,3S,5S)-5-amino-2-N,N-dibenzylamino-3-hydroxy-1,6-diphenylhexane (III) by making its crystalline acid addition salt, which can be used as such to produce Lopinavir/Ritonavir with high purity and yield. Formula III

Processes and intermediates for preparing retroviral protease inhibitors

The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.