192767-12-7

Basic information

• Product Name: Benzenemethanol, 3,4-bis(difluoromethoxy)-a-[4-[2,2,2-trifluoro-1-(trifluoromethyl)-1-[[2-(tri methylsilyl)ethoxy]methoxy]ethyl]phenyl]-
• CAS NO: 192767-12-7
• Molecular Formula: C24H26F10O5Si
• Molecular Weight: 612.537
• Mol File: 192767-12-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 3,4-bis(difluoromethoxy)-a-[4-[2,2,2-trifluoro-1-(trifluoromethyl)-1-[[2-(tri methylsilyl)ethoxy]methoxy]ethyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3,4-bis(difluoromethoxy)-a-[4-[2,2,2-trifluoro-1-(trifluoromethyl)-1-[[2-(tri methylsilyl)ethoxy]methoxy]ethyl]phenyl]-(192767-12-7)
• EPA Substance Registry System: Benzenemethanol, 3,4-bis(difluoromethoxy)-a-[4-[2,2,2-trifluoro-1-(trifluoromethyl)-1-[[2-(tri methylsilyl)ethoxy]methoxy]ethyl]phenyl]-(192767-12-7)

Safety Data

• Hazardous Substances Data: 192767-12-7(Hazardous Substances Data)

Upstream product

• 151103-08-1 4-difluoromethoxy-3-hydroxybenzaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 2402-72-4 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 106-37-6 1.4-dibromobenzene 
• 127842-54-0 3,4-bis-(difluoromethoxy)-benzaldehyde 
• 192767-03-6 2-(4-bromophenyl)-2-[2-(trimethylsilyl)ethoxymethoxy]-1,1,1,3,3,3-hexafluoropropane 

Downstream Products

• 192767-14-9 3-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-3-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-propionic acid ethyl ester 
• 491869-01-3 4-[2-(3,4-bisdifluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]ethyl]-3-methylpyridine-1-oxide 
• 192767-02-5 2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol 
• 524775-39-1 2-(4-{1-(3,4-bis-difluoromethoxy-phenyl)-2-[3-(1-hydroxy-ethyl)-1-oxy-pyridin-4-yl]-ethyl}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol 
• 524774-95-6 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-2-methyl-pyridine 
• 524774-86-5 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-methyl-pyridine 
• 604806-79-3 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridine-3-carbaldehyde 
• 524774-90-1 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-ethyl-pyridine 
• 604806-63-5 [4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-methanol 

Relevant articles and documents

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: Prevention of reactive intermediate formation and covalent binding

A detailed study directed towards metabolic stability optimization of the alkoxy substituents on the catechol moiety of CDP-840 is reported. Replacement of the methoxy and cyclopentyloxy substituents by cyclobutyloxy and/or difluromethoxy groups resulted in the discovery of potent and selective PDE4 inhibitors where the formation of reactive metabolites that could covalently bind to microsomal protein was significantly reduced or eliminated.

Substituted 4-(2,2-Diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

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