19281-12-0

Basic information

• Product Name: N-(2-Hydroxyethyl)-2-(3-nitrophenyl)acetamide
• Synonyms: N-(2-Hydroxyethyl)-2-(3-nitrophenyl)acetamide
• CAS NO: 19281-12-0
• Molecular Weight: 224.216
• Mol File: 19281-12-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-Hydroxyethyl)-2-(3-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Hydroxyethyl)-2-(3-nitrophenyl)acetamide(19281-12-0)
• EPA Substance Registry System: N-(2-Hydroxyethyl)-2-(3-nitrophenyl)acetamide(19281-12-0)

Safety Data

• Hazardous Substances Data: 19281-12-0(Hazardous Substances Data)

Upstream product

• 1877-73-2 3-nitro-benzeneacetic acid 
• 128625-52-5 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 
• 141-43-5 ethanolamine 
• 133611-16-2 (3-nitrophenyl)-acetic acid 2,5-dioxopyrrolidin-1-yl ester 

Downstream Products

• 1204777-59-2 2-(3-aminophenyl)-N-(2-hydroxyethyl)-acetamide 

Relevant articles and documents

POTASSIUM ION CHANNEL MODULATORS and USES THEREOF

Compounds of formula (I) and pharmacologically acceptable salts and pro-drugs thereof wherein: Ar1 and Ar2 are aryl or heteroaryl; a is 0 to 5; R1 is alkyl, halogen, haloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monoalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulphonyl, alkylsulphonylamino or cyano and, where a is greater than 1, each substituent R1 may be the same or different; b is 0 to 5; R2 is alkyl, halogen, haloalkyl, haloalkoxy, alkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monoalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulphonyl, alkylsulphonylamino or cyano and where b is greater than 1, each substituent R2 may be the same or different; V is selected from the group consisting of (CR3aR3b)pCON(R3b)X and (CR3aR3b)pN(R3b)CO(X), wherein said groups are in the 3- (meta) or 4- (para) position with respect to the substituent Z; W is selected from the group consisting of NR4a, O, S, S=O, SO2 and C(R4aR4b)2; X is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, haloalkoxyalkyl, aryloxyalkyl, cycloalkyl, aryl, heteroaryl, polyalkylene glycol, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkyl that is substituted with a groups of formula of formula NR8R9 wherein R8 and R9 together with the nitrogen atom to which they are attached form a saturated or partially unsaturated heterocyclic group, carboxyalkyl, alkoxycarbonylalkyl, haloalkoxycarbonylalkyl or aralkyloxycarbonylalkyl; Y and Z are the same or different and each is a substituent selected from the group consisting of (CR5aR5b)n1, C=O, SO2, C(=O)NR5a; C(=O)NR5aSO2 and C=O(R5aR5b)n2; R3a, R3b, R4a, R4b, R5a and R5b are the same or different and each is selected from the hydrogen, alkyl, cycloalkyl, aryl and heteroaryl; n1 and n2 are the same or different and each is 0 to 2; and p is 0 to 2; are potassium ion channel modulators, making them particularly useful in treating and preventing conditions such as pain, lower urinary tract disorders and the like.