19295-56-8

Basic information

• Product Name: Propanenitrile, 2,2-dimethyl-3-oxo-
• Synonyms: 2,2-dimethyl-2-cyanoacetaldehyde;Propanenitrile,2,2-dimethyl-3-oxo;2,2-dimethyl-3-oxo-propionitrile;2-cyano-2-methylpropional;2,2-Dimethyl-3-oxo-propionitril;2-cyano-2-methylpropanal
• CAS NO: 19295-56-8
• Molecular Formula: C5H7NO
• Molecular Weight: 97.1167
• Mol File: 19295-56-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 159.0±23.0 °C(Predicted)
• Density: 0.953±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Propanenitrile, 2,2-dimethyl-3-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanenitrile, 2,2-dimethyl-3-oxo-(19295-56-8)
• EPA Substance Registry System: Propanenitrile, 2,2-dimethyl-3-oxo-(19295-56-8)

Safety Data

• Hazardous Substances Data: 19295-56-8(Hazardous Substances Data)

Upstream product

• 126-98-7 methacrylonitrile 
• 201230-82-2 carbon monoxide 

Downstream Products

• 7321-55-3 2,2-dimethylmalononitrile 
• 1432123-22-2 N²-phenoxyacetyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)guanosine 
• 1432123-16-4 N⁶-phenoxyacetyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-[(N,N-diisopropylamino)(2-cyanoethyloxy)]phosphinyl-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)adenosine 
• 1432123-10-8 N⁴-phenoxyacetyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-[(N,N-diisopropylamino)(2-cyanoethyloxy)]phosphinyl-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)cytidine 
• 1401327-61-4 5’-O-(4,4’-dimethoxytrityl)-3’-O-[(N,N-diisopropylamino)(2-cyanoethyloxy)]phosphinyl-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine 
• 1432123-01-7 N²-phenoxyacetyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)guanosine 
• 1432122-98-9 N⁶-phenoxyacetyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)adenosine 
• 1432122-95-6 N⁴-phenoxyacetyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)cytidine 
• 1401327-38-5 5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine 
• 1432122-90-1 N²-phenoxyacetyl-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)guanosine 
• 1432122-87-6 N⁶-phenoxyacetyl-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)adenosine 
• 1432122-84-3 N⁴-phenoxyacetyl-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)cytidine 

Relevant articles and documents

Carbonylation (hydroformylation and hydrocarbalkoxylation) and enantioselective carbonylation of some methacrylic acid derivatives

The hydroformylation of methyl methacrylate (1) or t-butyl methacrylate (2) takes place with fair to good chemoselectivity, the regioselectivity depending on the catalyst precursor used.By contrast, methacrylonitrile (3), methacrylamide (4), and N-benzyl-methacrylamide (5) undergo hydroformylation followed by subsequent reactions.The formyl product formed is reduced to the corresponding 2-cyano-2-methylpropan-1-ol in the case of 3, and undergoes cyclization to 2-methyl-2,3-dehydrobutyrolactames for 4 and 5.Under conditions of hydrocarbalkoxylation in the presence of palladium catalysts, 4 gives 3-methylsuccinimide.In the enantioselective reactions, extents of asymmetric induction of about 20-50percent have been obtained.