193001-59-1

Basic information

• Product Name: 7-Quinazolinol, 4-[(4-chloro-2-fluorophenyl)amino]-6-methoxy-
• CAS NO: 193001-59-1
• Molecular Formula: C15H11ClFN3O2
• Molecular Weight: 319.723
• Mol File: 193001-59-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 7-Quinazolinol, 4-[(4-chloro-2-fluorophenyl)amino]-6-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Quinazolinol, 4-[(4-chloro-2-fluorophenyl)amino]-6-methoxy-(193001-59-1)
• EPA Substance Registry System: 7-Quinazolinol, 4-[(4-chloro-2-fluorophenyl)amino]-6-methoxy-(193001-59-1)

Safety Data

• Hazardous Substances Data: 193001-59-1(Hazardous Substances Data)

Upstream product

• 179688-01-8 6-methoxy-7-benzyloxyquinazoline-4-one 
• 617-05-0 ethyl vanillate 
• 185033-64-1 ethyl 4-benzyloxy-3-methoxybenzoate 
• 179688-01-8 7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one 
• 162364-72-9 7-benzyloxy-4-chloro-6-methoxyquinazoline 
• 193001-44-4 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride 
• 179688-01-8 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one 
• 60547-98-0 2-amino-4-benzyloxy-5-methoxybenzamide 
• 57946-56-2 2-fluoro-4-chloroaniline 

Downstream Products

• 196603-98-2 N-(4-chloro-2-fluorophenyl)-7-(3-chloropropoxy)-6-methoxyquinazolin-4-amine 
• 205193-35-7 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(2-(2-methoxyethoxy)ethoxy)quinazoline hydrochloride 
• 1312806-25-9 4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol 

Relevant articles and documents

QUINAZOLINE DERIVATIVE

Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.

Radiosynthesis of [11C]Vandetanib and [11C]chloro- Vandetanib as new potential PET agents for imaging of VEGFR in cancer

Vandetanib (ZD6474) and its chlorine analogue chloro-Vandetanib are potent and selective vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors with low nanomolar IC50 values. [ 11C]Vandetanib and [11C]chloro-Vandetanib, new potential PET agents for imaging of VEGFR in cancer, were first designed, synthesized and labeled at nitrogen and oxygen positions from their corresponding N- and O-des-methylated precursors, in 40-50% decay corrected radiochemical yield and 370-555 GBq/μmol specific activity at end of bombardment (EOB).

Quinazoline compounds

The invention concerns compounds of the formula (I) wherein ring A is phenyl or 5- or 6-membered heterocyclic ring as defined herein; Z is —O—, —NH— or —S—; m is an integer from 0 to 5 inclusive; R1 is hydrogen, hydroxy, halogeno, nitro, triflu