193085-32-4

Basic information

• Product Name: {2-[(tert-butoxycarbonyl)amino]-2-methylpropoxy}acetic acid
• Synonyms: {2-[(tert-Butoxycarbonyl)amino]-2-methylpropoxy}acetic acid
• CAS NO: 193085-32-4
• Molecular Formula: C₁₁H₂₁NO₅
• Molecular Weight: 247.2881
• Mol File: 193085-32-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 399.881°C at 760 mmHg
• Flash Point: 195.641°C
• Density: 1.106g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.464
• CAS DataBase Reference: {2-[(tert-butoxycarbonyl)amino]-2-methylpropoxy}acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[(tert-butoxycarbonyl)amino]-2-methylpropoxy}acetic acid(193085-32-4)
• EPA Substance Registry System: {2-[(tert-butoxycarbonyl)amino]-2-methylpropoxy}acetic acid(193085-32-4)

Safety Data

• Hazardous Substances Data: 193085-32-4(Hazardous Substances Data)

Usage

Description

2-[(tert-butoxycarbonyl)amino]-2-methylpropoxyacetic acid is a complex organic compound featuring a tert-butoxycarbonyl (Boc) protected amino group, a 2-methylpropoxy side chain, and an acetic acid functional group. The Boc group is utilized to shield the amino group from undesired reactions during organic synthesis, while the 2-methylpropoxy side chain contributes to the compound's hydrophobicity, influencing its solubility and pharmacokinetic properties. The acetic acid functional group allows for participation in a range of chemical reactions, making this compound a versatile molecule with potential applications in medicinal chemistry, organic synthesis, and other related fields.

Uses

Used in Medicinal Chemistry:
2-[(tert-butoxycarbonyl)amino]-2-methylpropoxyacetic acid is used as a building block for the development of new pharmaceuticals due to its unique structural features and reactivity. The Boc-protected amino group can be selectively deprotected when needed, enabling further functionalization and the creation of diverse drug candidates.
Used in Organic Synthesis:
In the field of organic synthesis, 2-[(tert-butoxycarbonyl)amino]-2-methylpropoxyacetic acid serves as an intermediate for the synthesis of more complex molecules. Its acetic acid functional group can be used in various reactions, such as esterification, amide formation, and other condensation reactions, to construct a wide array of organic compounds.
Used in Drug Delivery Systems:
2-[(tert-butoxycarbonyl)amino]-2-methylpropoxyacetic acid can be employed as a component in the design of drug delivery systems, taking advantage of its hydrophobic 2-methylpropoxy side chain to enhance the solubility and bioavailability of therapeutic agents. This may lead to improved pharmacokinetic properties and more effective drug administration.
Used in Chemical Research:
As a compound with distinct functional groups and properties, 2-[(tert-butoxycarbonyl)amino]-2-methylpropoxyacetic acid is used as a research tool in chemical laboratories to study reaction mechanisms, explore new synthetic routes, and develop innovative methodologies in organic chemistry.
Used in the Pharmaceutical Industry:
In the pharmaceutical industry, 2-[(tert-butoxycarbonyl)amino]-2-methylpropoxyacetic acid is used as a key component in the synthesis of various drug molecules, potentially leading to the development of novel therapeutics with improved efficacy and reduced side effects.

Upstream product

• 249762-00-3 (2-tert-butoxycarbonylamino-2-methyl-propoxy)-acetic acid ethyl ester 
• 102520-97-8 2-((tert-butyloxycarbonyl)amino)-2-methylpropan-1-ol 
• 623-73-4 diazoacetic acid ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 127958-62-7 5,5-dimethylmorpholin-3-one 

Downstream Products

• 193086-04-3 {1,1-dimethyl-2-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methoxy]-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

SUBSTITUTED N-HETEROCYCLIC CARBOXAMIDES AS ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS

The invention provides substituted N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

Compounds with growth hormone releasing properties

Compounds of peptide mimetic nature having the general formula I STR1 wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6 alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.

Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals

The structural requirements for N-terminal features for the minimal structure of growth hormone secretagogues derived from ipamorelin are investigated. It is found, that incorporation of nonpolar peptidomimetic amino acids at the N-terminal can replace the Aib-His moiety and lead to compounds with high in vitro potency with respect to their growth hormone secretagogue properties. New unnatural amino acids with double bonds, ether- linkages, and 1,3-phenylene-moieties in the backbone proved to be valuable dipeptidomimetics. Using them, growth hormone secretagogues with high potencies were obtained.