193274-82-7

Basic information

• Product Name: 1-BOC-3-BENZYL-PIPERIDIN-4-ONE
• Synonyms: 1-BOC-3-BENZYL-PIPERIDIN-4-ONE;tert-Butyl 3-benzyl-4-oxopiperidine-1-carboxylate;1-Piperidinecarboxylicacid, 4-oxo-3-(phenylmethyl)-, 1,1-dimethylethyl ester
• CAS NO: 193274-82-7
• Molecular Formula: C₁₇H₂₃NO₃
• Molecular Weight: 289.36942
• Product Categories: pharmacetical
• Mol File: 193274-82-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 409°Cat760mmHg
• Flash Point: 201.2°C
• Appearance: /
• Density: 1.115g/cm³
• Vapor Pressure: 6.69E-07mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: 2-8°C
• PKA: -1.58±0.40(Predicted)
• CAS DataBase Reference: 1-BOC-3-BENZYL-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-3-BENZYL-PIPERIDIN-4-ONE(193274-82-7)
• EPA Substance Registry System: 1-BOC-3-BENZYL-PIPERIDIN-4-ONE(193274-82-7)

Safety Data

• Hazardous Substances Data: 193274-82-7(Hazardous Substances Data)

Usage

General Description

1-BOC-3-BENZYL-PIPERIDIN-4-ONE is a chemical compound that is used in organic synthesis. It is a derivative of piperidine and has a BOC (tert-butoxycarbonyl) protecting group attached to the nitrogen atom. The benzyl group attached to the piperidine ring provides additional stability and reactivity to the molecule. 1-BOC-3-BENZYL-PIPERIDIN-4-ONE is commonly used as a building block in the synthesis of various pharmaceuticals and other organic compounds. It has applications in medicinal chemistry and drug discovery, as well as in the production of fine chemicals and advanced materials. The BOC protecting group can be removed under mild conditions, making 1-BOC-3-BENZYL-PIPERIDIN-4-ONE a valuable tool in chemical synthesis.

InChI:InChI=1/C17H23NO3/c1-17(2,3)21-16(20)18-10-9-15(19)14(12-18)11-13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3

Upstream product

• 188788-31-0 (3RS)-1,3-dibenzyl-piperidin-4-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 219324-21-7 1-tert-butyl 3-ethyl 3-benzyl-4-oxopiperidine-1,3-dicarboxylate 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 864973-53-5 3-benzyl-5-(1-hydroxy-1-methyl-propyl)-3-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer

We report here a catalytic method for the modular ring expansion of cyclic aliphatic alcohols. In this work, proton-coupled electron transfer activation of an allylic alcohol substrate affords an alkoxy radical intermediate that undergoes subsequent C-C bond cleavage to furnish an enone and a tethered alkyl radical. Recombination of this alkyl radical with the revealed olefin acceptor in turn produces a ring-expanded ketone product. The regioselectivity of this C-C bond-forming event can be reliably controlled via substituents on the olefin substrate, providing a means to convert a simple N-membered ring substrate to either n+1 or n+2 ring adducts in a selective fashion.

PIPERIDINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a compound represented by the formula: ???wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, R1 is a hydrogen atom, an optionally substituted hydroca

Heterocyclic compounds

This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenous growth hormone. The compounds of this invention are useful for the treatment and prevention of osteoporosis, congestive heart failure, frailty associated with aging, obesity; accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or patients having undergone major surgery; improving muscle strength, mobility, maintanence of skin thickness, metabolic homeostasis or renal homeostasis. The compounds of the present invention are also useful in treating osteoporosis when used in combination with: a bisphosphonate compound such as alendronate; estrogen, premarin, and optionally progesterone; an estrogen agonist or antagonist; or calcitonin, and pharmaceutical compositions useful therefor. Further, the present invention is directed to pharmaceutical compositions useful for increasing the endogenous production or release of growth hormone in a human or other animal which comprises an effective amount of a compound of the present invention and a growth hormone secretagogue selected from GHRP-6, Hexarelin, GHRP-1, growth hormone releasing factor (GRF), IGF-1, IGF-2 or B-HT920. The invention is also directed to intermediates useful in the preparation of compounds of formula I.