193276-49-2

Basic information

• Product Name: 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 3,10-dibroMo-8-chloro-6,11-dihydro-11-(4-piperidinyl)-, (11R)-
• Synonyms: 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 3,10-dibroMo-8-chloro-6,11-dihydro-11-(4-piperidinyl)-, (11R)-;3,10-dibromo-8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• CAS NO: 193276-49-2
• Molecular Formula: C₁₉H₁₉Br₂ClN₂
• Molecular Weight: 471
• EINECS: -0
• Mol File: 193276-49-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 3,10-dibroMo-8-chloro-6,11-dihydro-11-(4-piperidinyl)-, (11R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 3,10-dibroMo-8-chloro-6,11-dihydro-11-(4-piperidinyl)-, (11R)-(193276-49-2)
• EPA Substance Registry System: 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 3,10-dibroMo-8-chloro-6,11-dihydro-11-(4-piperidinyl)-, (11R)-(193276-49-2)

Safety Data

• Hazardous Substances Data: 193276-49-2(Hazardous Substances Data)

Upstream product

• 193276-48-1 (8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-yl)-1-piperidine 
• 108-22-5 Isopropenyl acetate 
• 102096-25-3 2,2,2-trifluoroethyl isobutyrate 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 272107-22-9 8-chloro-3,10-dibromo-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine 
• 193276-55-0 3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one 
• 165740-12-5 ethyl 4-(3-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate 
• 193276-47-0 4-<3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidine 
• 193276-46-9 4-<3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester 
• 193276-44-7 4-<3-bromo-8-chloro-5,6-dihydro-9-amino-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester 
• 193276-34-5 4-<3-bromo-8-chloro-5,6-dihydro-9-nitro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester 
• 193276-45-8 4-<3,10-dibromo-8-chloro-5,6-dihydro-9-amino-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester 

Downstream Products

• 193275-84-2 lonafarnib 

Relevant articles and documents

Process for producing (8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-B]pyridin-11-YL)-1-piperdine

A process for producing compounds of the formula: is disclosed. The compound of formula 1.0 is produced by: (1) separating the atropisomers of ?to obtain the atropisomers (2) heating the atropisomer of formula 2.0B at a suitable temperature in a suitable solvent to obtain a mixture of atropisomers of formulas 2.0A and 2.0B; (3) separating the atropisomers of formulas 2.0A and 2.0B of step (2); and (4) reducing the atropisomer of formula 2.0A to obtain a compound of formula 1.0. Preferably, R1is Br, R2is Cl and R3is Br. Also disclosed is the (+)-atropisomer of formula 2.0 wherein R1is Br, R2is Cl and R3is Br.

BENZO(5,6)CYCLOHEPTA(1,2B)PYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE

Novel compounds of formula: (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO; R and R are the same or different and each represents halo; R and R are each independently selected from H and halo, provided that at least one of R and R is H; each dotted line (---) represents an optional bond; X is N, C when the optional bond to X is present, or CH when the optional bond to X is absent; T is a substituent selected from (A) or (B): Z represents O or S; R represents -C(O)N(R)2, -CH2C(O)N(R), -SO2R, -SO2N(R)2, -C(O)R, -C(O)-O-R, alkyl, aryl, aralkyl, cycloalkyl, heterocycloalkyl or heteroaryl; R represents alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, OR, NRH, SH, SR, SOR (where R is not H) or SO2R (where R is not H); and each R independently represents H, alkyl, aryl, or aralkyl; R is alkyl, aryl, aralkyl, heteroaryl, or heterocycloalkyl; R is selected from H, alkyl, aryl, aralkyl, heteroaryl, heteroarylalkyl, or heterocycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.

COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE

Novel compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formula (1.4) or (1.5) wherein R, R and R are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.