193602-41-4

Basic information

• Product Name: RARECHEM AL BD 1228
• Synonyms: RARECHEM AL BD 1228;3-Chlorothiophene-2-methanol;(3-chlorothiophen-2-yl)methanol;(3-Chlorothiophen-2-yl)
• CAS NO: 193602-41-4
• Molecular Formula: C5H5ClOS
• Molecular Weight: 148.61
• Mol File: 193602-41-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 239.7±25.0 °C(Predicted)
• Appearance: /
• Density: 1.419±0.06 g/cm3(Predicted)
• PKA: 13.21±0.10(Predicted)
• CAS DataBase Reference: RARECHEM AL BD 1228(CAS DataBase Reference)
• NIST Chemistry Reference: RARECHEM AL BD 1228(193602-41-4)
• EPA Substance Registry System: RARECHEM AL BD 1228(193602-41-4)

Safety Data

• Hazardous Substances Data: 193602-41-4(Hazardous Substances Data)

Usage

General Description

RARECHEM AL BD 1228 is a chemical compound that contains multiple ingredients including benzene, 1,2,3-trimethyl-, trinitrate (TNT) and pentaerythritol tetranitrate. It is commonly used as an explosive material due to its highly stable and powerful nature. RARECHEM AL BD 1228 is known for its high resistance to heat and shock, making it suitable for military and industrial applications. However, it also presents significant hazards due to its potential explosiveness, and must be handled with extreme caution and expertise. Additionally, it has been found to contribute to environmental pollution and should be managed and disposed of in compliance with safety regulations.

Upstream product

• 59337-89-2 3-chlorothiophene-2-carboxylic acid 
• 89581-82-8 2-acetyl-3-chlorothiophene 
• 153562-66-4 ethyl 3-chlorothiophene-2-carboxylate 
• 67482-48-8 3-chlorothiophene-2-carboxaldehyde 
• 17249-80-8 3-chlorothiophene 
• 124-38-9 carbon dioxide 

Downstream Products

• 880165-67-3 2-(3-chlorothiophen-2-yl)acetonitrile 

Relevant articles and documents

IL4I1 INHIBITORS AND METHODS OF USE

Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

Benzoxazine compound and its preparation methods and application

The invention relates to a benzoxazine compound represented in the following formula 1. The benzoxazine compound can serve as a beta 2 receptor agonist. The formula can be seen from the description.

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and mutant myocilin. Grp94 has been implicated as a target for several therapeutic areas including glaucoma, cancer metastasis, and multiple myeloma. While 85% identical to other Hsp90 isoforms, the N-terminal ATP-binding site of Grp94 possesses a unique hydrophobic pocket that was used to design isoform-selective inhibitors. Incorporation of a cis-amide bioisostere into the radamide scaffold led to development of the original Grp94-selective inhibitor, BnIm. Structure-activity relationship studies have now been performed on the aryl side chain of BnIm, which resulted in improved analogues that exhibit better potency and selectivity for Grp94. These analogues also manifest superior antimigratory activity in a metastasis model as well as enhanced mutant myocilin degradation in a glaucoma model compared to BnIm.