19361-97-8

Basic information

• Product Name: 2-[(phenylsulfonyl)oxy]-1H-isoindole-1,3(2H)-dione
• Synonyms: Benzenesulfonic acid 1,3-dioxo-1,3-dihydro-isoindol-2-yl ester
• CAS NO: 19361-97-8
• Molecular Formula: C₁₄H₉NO₅S
• Molecular Weight: 303.29
• Mol File: 19361-97-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 487.2°C at 760 mmHg
• Flash Point: 248.5°C
• Density: 1.59g/cm³
• Vapor Pressure: 1.21E-09mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: 2-[(phenylsulfonyl)oxy]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(phenylsulfonyl)oxy]-1H-isoindole-1,3(2H)-dione(19361-97-8)
• EPA Substance Registry System: 2-[(phenylsulfonyl)oxy]-1H-isoindole-1,3(2H)-dione(19361-97-8)

Safety Data

• Hazardous Substances Data: 19361-97-8(Hazardous Substances Data)

Usage

Structure

It is a synthetic derivative of isoindoline, featuring a five-membered ring structure.

Applications

Pharmaceutical Research: Investigated for various medicinal purposes.
Anti-cancer Properties: Studied for its potential in combating cancer.
Anti-inflammatory Properties: Potential for reducing inflammation.
Angiogenesis Inhibition: Ability to hinder the growth of new blood vessels.
Treatment for Diabetic Retinopathy: Explored for its effectiveness in managing ocular diseases related to diabetes.
Cardiovascular Disease Therapies: Promising for the development of treatments for heart-related conditions.
Neurological Disorder Therapies: Potential applications in neurological disease management.

Value in Medicinal Chemistry

Considered a valuable candidate for further research and development in pharmaceuticals.

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 98-09-9 benzenesulfonyl chloride 
• 85-44-9 phthalic anhydride 
• 369-57-3 benzenediazonium tetrafluoroborate 

Downstream Products

• 65956-55-0 p-tolyl 2-(((p-tolyloxy)carbonyl)amino)benzoate 

Relevant articles and documents

One-pot synthesis and luminescent spectra of 3-allyl substituted quinazoline-2,4-dione derivatives as allyl capping agents

3-Nitro-N-(phenylsulphonyloxy)phthalimide (IIIa) and N-(phenylsulphonyloxy) phthalimide (IIIb) were synthesised as key intermediates in good yield. Their structures were confirmed by 1H NMR and FTIR spectral data. The reaction of the key intermediates with allylamine produced 3-allyl-5- nitroquinazoline-2,4-(1H,3H)-dione (IVa) and 3-allylquinazoline-2,4-(1H,3H)- dione (IVb), respectively. Luminescence emission and excitation spectra of IVa and IVb are also presented.

Highly Active Manganese to C?O Cross-Coupling Reaction for the Synthesis of N-Hydroxyphthalimide Esters

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Novel anthracene derivative and radiation-sensitive resin composition

A novel anthracene derivative useful as an additive to a radiation-sensitive resin composition is disclosed. The anthracene derivative has the following formula (1), wherein R1 groups individually represent a hydroxyl group or a monovalent organic group having 1-20 carbon atoms, n is an integer of 0-9, X is a single bond or a divalent organic group having 1-12 carbon atoms, and R2 represents a monovalent acid-dissociable group. The radiation-sensitive resin composition comprises the anthracene derivative of the formula (1), a resin insoluble or scarcely soluble in alkali, but becomes alkali soluble in the presence of an acid, and a photoacid generator. The composition is useful as a chemically-amplified resist for microfabrication utilizing deep ultraviolet rays, typified by a KrF excimer laser and ArF excimer laser.