193696-36-5

Basic information

• Product Name: 2-Butanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]phenyl]-1-phenyl-, (3S)-
• CAS NO: 193696-36-5
• Molecular Formula: C28H44O3Si2
• Molecular Weight: 484.827
• Mol File: 193696-36-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]phenyl]-1-phenyl-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]phenyl]-1-phenyl-, (3S)-(193696-36-5)
• EPA Substance Registry System: 2-Butanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]phenyl]-1-phenyl-, (3S)-(193696-36-5)

Safety Data

• Hazardous Substances Data: 193696-36-5(Hazardous Substances Data)

Upstream product

• 193696-34-3 (2S,3R)-2,4'-di-t-butyldimethylsiloxy-3-hydroxy-1,4-diphenylbutane 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 7339-87-9 4-hydroxyphenylacetaldehyde 
• 193696-30-9 (2S,3R)-3,4-epoxy-2-hydroxy-1-(4'-hydroxyphenyl)butane 
• 193696-32-1 (2S,3R)-3,4-epoxy-2,4'-di-t-butyldimethylsiloxy-1-phenylbutane 
• 193696-27-4 4-(2-hydroxy-but-3-enyl)-phenol 
• 193696-27-4 2-hydroxy-1-(4'-hydroxyphenyl)-3-butene 

Relevant articles and documents

Total syntheses of kurasoins A and B, novel protein farnesyltransferase inhibitors, and absolute structures of kurasoins A and B

Asymmetric total syntheses of kurasoins A (1) and B (2), recently discovered protein farnesyltransferase (PFTase) inhibitors, have been achieved in seven steps from 2-(4-hydroxyphenyl)ethanol via the stereospecific alkylation of the chiral epoxide ((-)-7) and in four steps from phenylacetaldehyde via the coupling reaction of the chiral epoxide ((-)- 13) with indole, respectively. The synthesis defined the (3S) absolute configuration of 1 and 2. The stereochemistry of the hydroxy group is important for eliciting PFTase inhibition.