193806-49-4

Basic information

• Product Name: Carbamic acid, N-[2-(2-hydroxyethyl)phenyl]-,1,1-dimethylethyl ester
• Synonyms: Carbamic acid, [2-(2-hydroxyethyl)phenyl]-,1,1-dimethylethyl ester (9CI)
• CAS NO: 193806-49-4
• Molecular Formula: C13H19 N O3
• Molecular Weight: 237.299
• Mol File: 193806-49-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, N-[2-(2-hydroxyethyl)phenyl]-,1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, N-[2-(2-hydroxyethyl)phenyl]-,1,1-dimethylethyl ester(193806-49-4)
• EPA Substance Registry System: Carbamic acid, N-[2-(2-hydroxyethyl)phenyl]-,1,1-dimethylethyl ester(193806-49-4)

Safety Data

• Hazardous Substances Data: 193806-49-4(Hazardous Substances Data)

Usage

General Description

Carbamic acid, N-[2-(2-hydroxyethyl)phenyl]-,1,1-dimethylethyl ester, also known as carbetapentane, is a chemical compound commonly used as an antitussive (cough suppressant) in the treatment of coughs. It belongs to the class of chemicals known as carbamic acid esters and is a derivative of the phenethylamine class of compounds. Carbetapentane works by depressing the cough reflex in the central nervous system, providing relief from coughing. It is often used in over-the-counter cough and cold medications and is generally considered to be a safe and effective treatment for coughs when used as directed. However, it may have potential side effects and interactions with other medications, so it is important to use it under the guidance of a healthcare professional.

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
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• 24424-99-5 di-tert-butyl dicarbonate 
• 5339-85-5 2-aminophenethyl alcohol 

Downstream Products

• 193806-50-7 2-(mesyloxy)-1-[2-[(tert-butoxycarbonyl)amino]phenyl]ethane 
• 496-15-1 1-indoline 
• 193806-62-1 2-Allyl-2-[2-(2-tert-butoxycarbonylamino-phenyl)-ethylsulfanylcarbonylmethyl]-malonic acid diethyl ester 
• 193806-60-9 2-Allyl-4-nitro-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-57-4 2-(2-Methyl-allyloxy)-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-58-5 2-Prop-2-ynyloxy-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-61-0 2-Allyl-5-methoxy-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-56-3 2-Allyloxy-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-59-6 2-Allyl-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-51-8 Thioacetic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-48-3 [2-(2-Mercapto-ethyl)-phenyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

NOVEL 4-(2FUROYL)AMINOPIPERIDINES, INTERMEDIATES IN SYNTHESIZING THE SAME,PROCESS FOR PRODUCING THE SAME AND MEDICINAL USE OF THE SAME

There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N-R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like.The 4-(2-furoyl) aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

Radical ring closures of 4-isocyanato carbon-centered radicals

The 2-(2-isocyanatophenyl)ethyl radical was generated from the corresponding bromide with tributyltin and tris(trimethylsilyl)silyl radicals and shown to ring close in the 6-endo-mode to afford 3,4-dihydro-1H-quinolin-2-one as the major product. Cyclization in the 5-exo-mode to produce 2,3-dihydroindole-1-carbaldehyde, after hydrogen abstraction, was a minor reaction. Rate constants for the two processes were estimated and compared with reaction enthalpies computed by the DFT method.