193814-78-7

Basic information

• Product Name: Carbamic acid, [1-(fluorocarbonyl)-3-butenyl]-, 1,1-dimethylethyl ester, (S)-
• Synonyms: Carbamic acid, [1-(fluorocarbonyl)-3-butenyl]-, 1,1-dimethylethyl ester, (S)-
• CAS NO: 193814-78-7
• Molecular Formula: C₁₀H₁₆FNO₃
• Molecular Weight: 217.2373432
• Product Categories: N-BOC
• Mol File: 193814-78-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 299.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.064±0.06 g/cm3(Predicted)
• PKA: 10.82±0.46(Predicted)
• CAS DataBase Reference: Carbamic acid, [1-(fluorocarbonyl)-3-butenyl]-, 1,1-dimethylethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1-(fluorocarbonyl)-3-butenyl]-, 1,1-dimethylethyl ester, (S)-(193814-78-7)
• EPA Substance Registry System: Carbamic acid, [1-(fluorocarbonyl)-3-butenyl]-, 1,1-dimethylethyl ester, (S)-(193814-78-7)

Safety Data

• Hazardous Substances Data: 193814-78-7(Hazardous Substances Data)

Upstream product

• 90600-20-7 (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid 

Downstream Products

• 193814-84-5 (S)-2-[(S)-4-(Biphenyl-4-yloxy)-2-tert-butoxycarbonylamino-butyryl]-3-methylcarbamoyl-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 193814-83-4 (S)-2-((S)-2-tert-Butoxycarbonylamino-4-hydroxy-butyryl)-3-methylcarbamoyl-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 193814-82-3 (S)-2-((S)-2-tert-Butoxycarbonylamino-pent-4-enoyl)-3-methylcarbamoyl-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 193814-80-1 (S)-2-((S)-2-tert-Butoxycarbonylamino-pent-4-enoyl)-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 

Relevant articles and documents

Potent carboxylate inhibitors of stromelysin containing P2' piperazic acids and P1' biaryl moeities

Several carboxylate derivatives with variation at the P1' residue were synthesized and evaluated as stromelysin (MMP-3) inhibitors. Compounds containing a bipbenyl moiety at P1' were found to be potent inhibitors of MMP-3. An X-ray crystal structure of the most potent compound, carboxylate 19, revealed an important interaction between the inhibitor's biphenyl and histidine 224 in the S1' pocket of MMP-3.