193882-70-1

Basic information

• Product Name: Benzoic acid, 5-iodo-2-(2-propenyloxy)-, methyl ester
• CAS NO: 193882-70-1
• Molecular Formula: C11H11IO3
• Molecular Weight: 318.111
• Mol File: 193882-70-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-iodo-2-(2-propenyloxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-iodo-2-(2-propenyloxy)-, methyl ester(193882-70-1)
• EPA Substance Registry System: Benzoic acid, 5-iodo-2-(2-propenyloxy)-, methyl ester(193882-70-1)

Safety Data

• Hazardous Substances Data: 193882-70-1(Hazardous Substances Data)

Upstream product

• 4068-75-1 methyl 5-iodosalicylate 
• 106-95-6 allyl bromide 

Downstream Products

• 193882-69-8 2-(allyloxy)-5-iodobenzoic acid 

Relevant articles and documents

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS AND USES THEREOF

Described herein are ASK1 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of blood disease, autoimmune disorders, pulmonary disorders, hypertension, inflammatory diseases, fibrotic diseases, diabetes, diabetic nephropathy, renal diseases, respiratory diseases, cardiovascular diseases, acute lung injuries, acute or chronic liver diseases, and neurodegenerative diseases.

Synthesis and 5-HT-3 receptor binding activity of 5-[125I]iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl]benzamide and its 5-halogen-2-alkoxyl homologues

(S)-5-Iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (MIZAC) was prepared from 5-iodo-2,3-dimethoxybenzoyl chloride and (S)-3-aminoquinuclidine. [125I]Iodode-stannylation of its corresponding 5-tri-n-butyltin derivative gave [125I]-MIZAC at 1800 Ci/mmol. Binding of [125I]-MIZAC in rat entorhinal cortex revealed a K(D) of 1.37 ± 0.21 nM. A series of racemic 2-O-alkyl derivatives of MIZAC were prepared and 5-HT-3 receptor affinities were determined by inhibition of [125I]-MIZAC binding. Optimal affinity for the receptor was obtained with small, electron-withdrawing substituents in the aromatic 5-position and with bulky substituents in the 3-position. [125I]-MIZAC is a selective radioligand useful for in vitro identification of the 5-HT-3 receptor.