193882-72-3Relevant articles and documents
Alkylacetylene substituted Acyltryptophanols
-
Page/Page column 31, (2009/02/10)
The present invention relates to acyltryptophanols of the general formula I, in which R1, R2, R3, Q and X have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example fo
Alpha-alkyl substituted N-acyltryptophanols
-
Page/Page column 40; 41, (2009/03/07)
The present invention relates to α-alkyl substituted N-acyltryptophanols of the formula I in which R1, R2, R3, R4, R5, R6, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators
Iino, Tomoharu,Tsukahara, Daisuke,Kamata, Kenji,Sasaki, Kaori,Ohyama, Sumika,Hosaka, Hideka,Hasegawa, Takuro,Chiba, Masato,Nagata, Yasufumi,Eiki, Jun-ichi,Nishimura, Teruyuki
experimental part, p. 2733 - 2743 (2009/09/08)
Identification and synthesis of novel 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as glucokinase activators are described. Removal of an aniline structure of the prototype lead (2a) and incorporation of an alkoxy or phenoxy substituent led to the identifica