19407-66-0

Basic information

• Product Name: 7-chloro-2-(4-methoxyphenyl)quinazolin-4(3H)-one
• Synonyms: 7-chloro-2-(4-methoxyphenyl)quinazolin-4(3H)-one
• CAS NO: 19407-66-0
• Molecular Weight: 286.718
• Mol File: 19407-66-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-chloro-2-(4-methoxyphenyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-2-(4-methoxyphenyl)quinazolin-4(3H)-one(19407-66-0)
• EPA Substance Registry System: 7-chloro-2-(4-methoxyphenyl)quinazolin-4(3H)-one(19407-66-0)

Safety Data

• Hazardous Substances Data: 19407-66-0(Hazardous Substances Data)

Upstream product

• 33017-86-6 7-chloro-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 
• 342623-34-1 methyl 4-chloro-2-isothiocyanatobenzoate 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 5720-07-0 4-methoxyphenylboronic acid 
• 40928-13-0 4-chloroisatoic anhydride 
• 123-11-5 4-methoxy-benzaldehyde 
• 34662-32-3 4-chloro-2-nitrobenzonitrile 
• 7722-84-1 dihydrogen peroxide 
• 38487-86-4 2-amino-4-chlorobenzonitrile 
• 100-07-2 4-methoxy-benzoyl chloride 

Relevant articles and documents

Conversion of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones to N(3)-unsubstituted 2-(het)arylquinazolin-4(3H)-ones by copper-mediated Pd-catalysed cross-coupling reactions

With the purpose of searching for new heterocyclic building blocks, a new method to access N(3)-unsubstituted 2-(het)arylquinazolin-4(3H)-ones from 2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives was developed. The synthetic protocol was based on the copper-mediated palladium-catalysed cross-coupling reactions of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones with (het)arylstannanes or their S-benzylated derivatives with (het)arylboronic acids, using CuBr·Me2S and CuMeSal as promoters, respectively. A similar transformation was applied for the preparation of 2-aryl[1]benzothieno[3,2-d]pyrimidin-4(3H)-ones.