194088-59-0Relevant articles and documents
Potent selective thienoxazinone inhibitors of herpes proteases
Jarvest, Richard L.,Connor, Susan C.,Gorniak, Joselina G.,Jennings, L. John,Serafinowska, Halina T.,West, Andrew
, p. 1733 - 1738 (2007/10/03)
Thieno[3,2-d]oxazinones are potent, selective, mechanism-based inhibitors of the herpes proteases with good aqueous stability. Specificity between the HSV and CMV proteases varies across the series: compounds 14b and 14c are submicromolar HSV protease inhibitors with modest CMV protease inhibition, 14g is a selective CMV protease inhibitor, and 32 inhibits both enzymes with an IC50 of about 1 μM.
