194142-12-6

Basic information

• Product Name: 3-Thiophenepropanoic acid, 5-(4-methylphenyl)-
• CAS NO: 194142-12-6
• Molecular Formula: C14H14O2S
• Molecular Weight: 246.33
• Mol File: 194142-12-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Thiophenepropanoic acid, 5-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Thiophenepropanoic acid, 5-(4-methylphenyl)-(194142-12-6)
• EPA Substance Registry System: 3-Thiophenepropanoic acid, 5-(4-methylphenyl)-(194142-12-6)

Safety Data

• Hazardous Substances Data: 194142-12-6(Hazardous Substances Data)

Upstream product

• 649569-67-5 4-chloromethyl-2-p-tolyl-thiophene 
• 194142-13-7 3-(5-p-tolyl-thiophen-3-yl)-propionic acid ethyl ester 
• 101973-77-7 Esonarimod 

Relevant articles and documents

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.