194161-13-2 Usage
Description
(1R)-1-(2,6-difluorophenyl)-3H-[1,3]thiazolo[3,4-a]benzimidazole is a chemical compound with the molecular formula C13H8F2N2S. It belongs to the class of thiazole benzimidazoles and is a potent inhibitor of the enzyme poly(ADP-ribose) polymerase (PARP). PARP plays a crucial role in DNA repair, and inhibitors of this enzyme have shown promise in cancer therapy, especially in combination with chemotherapy and radiation.
Uses
Used in Cancer Therapy:
(1R)-1-(2,6-difluorophenyl)-3H-[1,3]thiazolo[3,4-a]benzimidazole is used as a therapeutic agent for the treatment of various types of cancers, including breast, ovarian, and prostate cancers. Its ability to inhibit PARP makes it a promising candidate for use in combination with chemotherapy and radiation to enhance the effectiveness of cancer treatments.
Used in Inflammatory and Autoimmune Disease Treatment:
(1R)-1-(2,6-difluorophenyl)-3H-[1,3]thiazolo[3,4-a]benzimidazole is also being studied for its potential in the treatment of inflammatory and autoimmune diseases. Its exact role and mechanism in these conditions are still under investigation, but its potential as a therapeutic agent is being explored in ongoing research and clinical trials.
Further research and clinical trials are ongoing to explore the full potential of this compound in the field of medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 194161-13-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,1,6 and 1 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 194161-13:
(8*1)+(7*9)+(6*4)+(5*1)+(4*6)+(3*1)+(2*1)+(1*3)=132
132 % 10 = 2
So 194161-13-2 is a valid CAS Registry Number.
194161-13-2Relevant articles and documents
One-pot synthesis of 1-aryl-1 H,3 H-thiazolo[3,4-a[benzimidazoles using magnetite-linked sulfonic acid as catalyst
Wu, Liqiang,Wang, Xiao
, p. 1851 - 1857 (2015/10/29)
A series of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazole derivatives have been synthesized via the three-component reaction of o-phenylenediamine, aromatic aldehydes, and 2-mercaptoacetic acid, catalyzed by magnetite-linked sulfonic acid. This method has the
Anti-HIV agents II. synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles
Chimirri,Grasso,Monforte,Monforte,Zappala
, p. 925 - 933 (2007/10/02)
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