1943-95-9

Basic information

• Product Name: 3-Cyclohexylphenol
• Synonyms: 3-Cyclohexylphenol;m-Cyclohexylphenol
• CAS NO: 1943-95-9
• Molecular Formula: C₁₂H₁₆O
• Molecular Weight: 176.26
• Mol File: 1943-95-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 300℃
• Flash Point: 152℃
• Appearance: /
• Density: 1.042
• Vapor Pressure: 0.00063mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-Cyclohexylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclohexylphenol(1943-95-9)
• EPA Substance Registry System: 3-Cyclohexylphenol(1943-95-9)

Safety Data

• Hazardous Substances Data: 1943-95-9(Hazardous Substances Data)

Usage

General Description

3-Cyclohexylphenol is a chemical compound primarily used in the field of organic synthesis. It is typically found as a light yellow liquid. Known also by its IUPAC name, 3-Phenylcyclohexanol, it is identified by its CAS Registry Number, 25189-55-3. The chemical falls under the class of phenols, compounds containing a phenol group which is a ring of six carbon atoms attached to a hydroxyl (OH) group. 3-Cyclohexylphenol is considered hazardous and may cause eye, skin, and respiratory irritation upon exposure. It can potentially interfere with biological processes with its phenol group.

InChI:InChI=1/C12H16O/c13-12-8-4-7-11(9-12)10-5-2-1-3-6-10/h4,7-10,13H,1-3,5-6H2

Upstream product

• 41876-58-8 1-cyclohexyl-3-methoxybenzene 
• 57568-54-4 2-(3-cyclohexylphenoxy)propionic acid 
• 2206-38-4 cyclohexylphenyl ether 
• 1131-60-8 p-cyclohexylphenol 
• 7446-70-0 aluminium trichloride 
• 542-18-7 cyclohexyl chloride 
• 108-90-7 chlorobenzene 
• 110-83-8 cyclohexene 
• 108-95-2 phenol 
• 108-93-0 cyclohexanol 
• 70907-47-0 2-(3-Cyclohexylphenoxy)propionsaeureethylester 
• 1884-41-9 1-Cyclohex-1-enyl-3-methoxy-benzene 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 108-94-1 cyclohexanone 

Downstream Products

• 57568-56-6 4-cyclohexyl-2-hydroxy-α-oxophenylacetic acid 
• 1131-60-8 p-cyclohexylphenol 
• 70907-47-0 2-(3-Cyclohexylphenoxy)propionsaeureethylester 
• 57568-37-3 6-cyclohexyl-2,3-dihydrobenzofuran-2-one 
• 57568-53-3 6-cyclohexyl-2,3-dihydro-3-methylbenzofuran-2-one 
• 79395-94-1 6-cyclohexyl-2,3-dihydro-3-(1,3-dithiolan-2-yl)benzofuran-2-one 
• 57568-57-7 3-acetoxy-6-cyclohexyl-2,3-dihydro-3-methylbenzofuran-2-one 
• 70907-53-8 2-(3-Cyclohexylphenoxy)propionitril 
• 70907-50-5 2-(3-Cyclohexylphenoxy)propionamid 
• 70907-56-1 2-(3-Cyclohexylphenoxy)propionamidoxim 
• 57568-54-4 2-(3-cyclohexylphenoxy)propionic acid 

Relevant articles and documents

Acid-Catalyzed Hydrolysis of Some Secondary Alkyl Phenyl Ethers in Perchloric Acid: Kinetics and Mechanism

Hydrolysis rates and products of isopropyl, cyclopentyl and cyclohexyl phenyl ethers were studied in concentrated aqueous perchloric acid solutions.The activation parameters, solvent deuterium isotope effects, dependences of the reaction rates on acid concentration, substituent effects and products were in agreement with the A-1 mechanism.The pKSH+ values (-6.13 to -5.76) and the slope parameters m* (av. 0.98 +/- 0.03) were measured spectrophotometrically by the excess acidity method.They were used to calculate the m++-parameters (1.46-2.01).Comparisons weremade with the hydrolyses of exo- ad endo-2-norbornyl phenyl ethers and secondary alyl methanesulfonates.

Preparation of diphenolics

A process for the production of diphenolic compounds having a divalent bridge. A first disubstituted phenol is reacted with an aldehyde in the presence of a secondary amine and excess alcohol to form an ether intermediate. The ether intermediate is reacted with a phenol having an open ortho or para position to form a diphenolic.

Basic ethers of cyclohexylphenols with β blocking activity. Synthesis and pharmacological study of exaprolol

The paper discribes the preparation and study of the pharmacological properties of the basic ethers of cyclohexylphenols. The compounds with a single cycloaliphatic radical ortho to the basic chain, and in particular the one with a cyclohexyl (exaprolol), were found to be particularly active in blocking the β adrenergic receptors, as antiarrhythmics and local anesthetics, while the introduction of a second radical or the shift of the cycloaliphatic radical to meta or para position caused the said pharmacological activities to disappear almost entirely, with the exception of the local anesthetic action.