19432-66-7Relevant articles and documents
Practical preparation of ethyl 2-methylthiophene-3-carboxylate
Kogami, Masakazu,Watanabe, Nobuhide
, p. 797 - 798 (2011)
A safe and efficient process for the preparation of ethyl 2-methylthiophene-3-carboxylate (5) was devised. This process provides several advantages over the precedents, involving operational simplicity, avoidance of the use of strong bases such as n-butyllithium and application of noncryogenic conditions, and enabled to prepare 5 in 52% overall yield from commercially available 2-methylthiophene on a multikilogram scale.
Convenient method for the preparation of the 2-methyl thiophen-3-yl magnesium bromide lithium chloride complex and its application to the synthesis of 3-substituted 2-methylthiophenes
Kogami, Masakazu,Watanabe, Nobuhide
, p. 681 - 688 (2013/01/15)
Lithium chloride was found to accelerate formation of the Grignard reagent from inactive 3-bromo-2-methylthiophene (1) and commercial magnesium metal. Based on this finding, a convenient and potentially scalable preparation of ethyl 2-methylthiophene-3-ca
Preparation of 2,3-Disubstituted-4,5-dihydrothiphenes and Thiophenes Using the Intramolecular Non-classical Wittig Reaction of Thiocarboxylates
Chatterjee, Pallab,Murphy, Patrick J.,Pepe, Rosanna,Shaw, Michael
, p. 2403 - 2406 (2007/10/02)
2-Ethoxycarbonylcyclopropyl(triphenyl)phosphonium fluoroborate 1 reacts with alkali-methal thiolates to give 2,3-disubstituted 4,5-dihydrothiophnes 3 which can be aromatised to the corresponding thiophenes 5.