194423-93-3

Basic information

• Product Name: 2-Quinoxalinecarboxylic acid, 3-[[4-(ethoxycarbonyl)phenyl]amino]-7-(trifluoromethyl)-, ethyl ester
• CAS NO: 194423-93-3
• Molecular Formula: C21H18F3N3O4
• Molecular Weight: 433.387
• Mol File: 194423-93-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Quinoxalinecarboxylic acid, 3-[[4-(ethoxycarbonyl)phenyl]amino]-7-(trifluoromethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Quinoxalinecarboxylic acid, 3-[[4-(ethoxycarbonyl)phenyl]amino]-7-(trifluoromethyl)-, ethyl ester(194423-93-3)
• EPA Substance Registry System: 2-Quinoxalinecarboxylic acid, 3-[[4-(ethoxycarbonyl)phenyl]amino]-7-(trifluoromethyl)-, ethyl ester(194423-93-3)

Safety Data

• Hazardous Substances Data: 194423-93-3(Hazardous Substances Data)

Upstream product

• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 
• 143948-79-2 ethyl 3-oxo-7-(trifluoromethyl)-3,4-dihydroquinoxaline-2-carboxylate 
• 94-09-7 p-aminoethylbenzoate 
• 194423-79-5 ethyl 3-chloro-7-(trifluoromethyl)quinoxaline-2-carboxylate 

Relevant articles and documents

Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2- [aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity

Thirty-three quinoxalines bearing an aminobenxoyl or aminobenzoylglutammate group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 molar concentrations. Interesting selectivities were also recorded between 10-8 and 10-6. Among the series examined one compound (29) which was the most active also exhibited both in vitro anti-HIV protection and antifungal activity while in other two (31.37) the antifungal activity was prevailing.