194491-61-7

Basic information

• Product Name: 1,2-Ethanediol, 1-(2,4-difluorophenyl)-1-[4-(2,4-difluorophenyl)-2-thiazolyl]-, (R)-
• CAS NO: 194491-61-7
• Molecular Formula: C17H11F4NO2S
• Molecular Weight: 369.339
• Mol File: 194491-61-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-Ethanediol, 1-(2,4-difluorophenyl)-1-[4-(2,4-difluorophenyl)-2-thiazolyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanediol, 1-(2,4-difluorophenyl)-1-[4-(2,4-difluorophenyl)-2-thiazolyl]-, (R)-(194491-61-7)
• EPA Substance Registry System: 1,2-Ethanediol, 1-(2,4-difluorophenyl)-1-[4-(2,4-difluorophenyl)-2-thiazolyl]-, (R)-(194491-61-7)

Safety Data

• Hazardous Substances Data: 194491-61-7(Hazardous Substances Data)

Upstream product

• 194491-59-3 2,4-difluorophenyl [4-(2,4-difluorophenyl)thiazol-2-yl] ketone 
• 106614-28-2 methyl 2,4-difluorobenzoate 
• 194491-60-6 1-(2,4-difluorophenyl)-1-[4-(2,4-difluorophenyl)thiazol-2-yl]ethene 

Downstream Products

• 1026817-08-2 Methanesulfonic acid (R)-2-(2,4-difluoro-phenyl)-2-[4-(2,4-difluoro-phenyl)-thiazol-2-yl]-2-hydroxy-ethyl ester 

Relevant articles and documents

Synthesis and antifungal activity of novel thiazole-containing triazole antifungals

A new series of thiazole-containing triazole antifungals was synthesized and evaluated for antifungal activity against a variety of clinically isolated pathogenic fungi in vitro and against systemic candidosis in vivo. Among these compounds, (±)-1-(2,4-difluorophenyl)-1-[4-(2,4- difluorophenyl)thiazol-2-yl]-2-(1H-1,2,4-triazol-1-yl)ethanol (ER24161) showed the most potent and well-balanced in vitro activities and excellent in vivo efficacy. We also achieved an enantioselective synthesis of the more potent enantiomer of ER-24161.