19466-30-9

Basic information

• Product Name: Benzene, 1-fluoro-3-(2-phenylethenyl)-, (Z)-
• CAS NO: 19466-30-9
• Molecular Formula: C14H11F
• Molecular Weight: 198.24
• Mol File: 19466-30-9.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: Benzene, 1-fluoro-3-(2-phenylethenyl)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-fluoro-3-(2-phenylethenyl)-, (Z)-(19466-30-9)
• EPA Substance Registry System: Benzene, 1-fluoro-3-(2-phenylethenyl)-, (Z)-(19466-30-9)

Safety Data

• Hazardous Substances Data: 19466-30-9(Hazardous Substances Data)

Upstream product

• 1868-53-7 dibromofluoromethane 
• 13189-30-5 1-phenylspiro<2.4>hepta-4,6-diene 
• 100-42-5 styrene 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 462-06-6 fluorobenzene 
• 456-48-4 3-Fluorobenzaldehyde 
• 29778-28-7 1-fluoro-3-(2-phenylethynyl)benzene 
• 14595-77-8 bis(trimethylsilyl)phenylmethane 
• 350-51-6 3-fluorostyrene 
• 71-43-2 benzene 
• 536-74-3 phenylacetylene 
• 100-39-0 benzyl bromide 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 

Downstream Products

• 523-41-1 2-Fluor-phenanthren 
• 1346939-26-1 (E)-4-methyl-4′-styryl-1,1-biphenyl 

Relevant articles and documents

Electrochemical Proton Reduction over Nickel Foam for Z-Stereoselective Semihydrogenation/deuteration of Functionalized Alkynes

Selective reduction strategies based on abundant-metal catalysts are very important in the production of chemicals. In this paper, a method for the electrochemical semihydrogenation and semideuteration of alkynes to form Z-alkenes was developed, using a simple nickel foam as catalyst and H3O+ or D3O+ as sources of hydrogen or deuterium. Good yields and excellent stereoselectivities (Z/E up to 20 : 1) were obtained under very mild reaction conditions. The reaction proceeded with terminal and nonterminal alkynes, and also with alkynes containing easily reducible functional groups, such as carbonyl groups, as well as aryl chlorides, bromides, and even iodides. The nickel-foam electrocatalyst could be recycled up to 14 times without any change in its catalytic properties.

Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination

Mizoroki-Heck reaction of unstrained aryl ketone with acrylate/styrene is accomplished via palladium-catalyzed ligand-promoted C-C bond cleavage. Various (hetero)aryl ketones are compatible in the reaction, affording the alkene product in good to excellent yields. Further applications in the late-stage olefination of some drugs, natural products, and fragrance-derived aryl ketones demonstrate the synthetic utility of this protocol. By employing ketone as both the directing group and the leaving group, 1,2-bifunctionalization is achieved via sequential ortho-C-H alkylation/ipso-Heck olefination.

Method for synthesizing trans-olefin compound

The invention discloses a trans-olefin compound synthesis method, which comprises: carrying out a heating reaction on an alkyne compound represented by a general formula (I), a reducing agent and a solvent to obtain a trans-olefin compound represented by a general formula (II), wherein the synthesis route is as follows: R1 and R2 are independently selected from hydrogen, alkyl, cycloalkyl or aryl;wherein the reducing agent is a sulfur-containing compound and is selected from at least one of thioacetamide, N,N-dimethyl dithiocarbamate dimethyl ammonium salt, dimethyl amino sodium dithioformatedihydrate, potassium ethyl xanthate and potassium isopropyl xanthate. According to the method, a cheap, efficient and safe reducing agent is utilized to realize high-selectivity reduction of alkyne to prepare trans-olefin under the condition of no transition metal catalysis, so that the method is simple and easy to implement, wide in substrate application range and easy to realize industrialization.