194785-79-0 Usage
Description
(S)-2-AMINO-7-HYDROXYTETRALIN HYDROBROMIDE, with the molecular formula C10H13NO.HBr, is a hydrobromide salt of the amino acid derivative 2-amino-7-hydroxytetralin. This chemical compound is recognized for its potential pharmaceutical applications, particularly in the field of neuropharmacology. It has been studied for its potential role in the treatment of psychiatric and neurological disorders, as well as in the modulation of neurotransmitter activity. The hydrobromide salt form enhances its solubility in water, facilitating its use in experimental and pharmaceutical settings.
Uses
Used in Pharmaceutical Industry:
(S)-2-AMINO-7-HYDROXYTETRALIN HYDROBROMIDE is used as a compound for the development of treatments targeting psychiatric and neurological disorders. Its application is based on its potential to modulate neurotransmitter activity, which can contribute to the management and treatment of these conditions.
Used in Research and Development:
In the field of neuroscience, (S)-2-AMINO-7-HYDROXYTETRALIN HYDROBROMIDE serves as a valuable research tool for studying the mechanisms underlying various psychiatric and neurological disorders. Its role in modulating neurotransmitter activity makes it instrumental in advancing our understanding of these complex conditions and developing targeted therapies.
Used in Drug Formulation:
The improved solubility of (S)-2-AMINO-7-HYDROXYTETRALIN HYDROBROMIDE in water due to its hydrobromide salt form makes it suitable for use in drug formulation. This characteristic facilitates the development of pharmaceutical products that can be more easily absorbed and distributed within the body, potentially leading to more effective treatments for the targeted conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 194785-79-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,7,8 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 194785-79:
(8*1)+(7*9)+(6*4)+(5*7)+(4*8)+(3*5)+(2*7)+(1*9)=200
200 % 10 = 0
So 194785-79-0 is a valid CAS Registry Number.
194785-79-0Relevant articles and documents
SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
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, (2012/02/01)
This invention provides compounds of formula (I): wherein R1, R1b, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
PREPARATION OF AMINOTETRALIN COMPOUNDS
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Page/Page column 12, (2010/08/08)
The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.
The practical synthesis of a uterine relaxant, Bis( 2-{[(2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl) -phenyl]ethyl}amino) -1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide) sulfate (KUR-1246)
Yanagi, Takashi,Kikuchi, Ken,Takeuchi, Hideki,Ishikawa, Takehiro,Nishimura, Toshihiro,Yamamoto, Iwao
, p. 1018 - 1023 (2007/10/03)
The synthetic route for a uterine relaxant, bis(2-{[ (2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3- (2-hydroxyethyl)-phenyl]ethyl}amino) -1,2,3,4-tetrahydronaphthalen-7-y1]oxy}-N,N-dimethylacetamide) sulfate (KUR-1246), was established by the coupling of optically active components, the bromohydrin 14 and the amine 24. We now describe the practical synthesis of these two optically active components. Bromohydrin 14 was obtained by the asymmetric borane reduction of the prochiral phenacyl bromide 13 using a catalyst prepared from aluminum triethoxide and a chiral amino alcohol. The other optically active component 24 was prepared from (S)-AMT.
