194981-56-1Relevant articles and documents
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human PPaR γ, δ and α agonists
Adams, Alan D.,Yuen, Winston,Hu, Zao,Santini, Conrad,Jones, A. Brian,MacNaul, Karen L.,Berger, Joel P.,Doebber, Thomas W.,Moller, David E.
, p. 931 - 935 (2003)
A series of amphipathic 3-phenylbenzisoxazoles were found to be potent agonists of human PPARα, γ and δ. The optimization of acid proximal structure for in vitro and in vivo potency is described. Results of po dosed efficacy studies in the db/db mouse mod