194986-17-9Relevant articles and documents
2,7-Diazabicyclo[3.3.0]octanes as novel h5-HT(1D) receptor agonists
Russell, Michael G. N.,Beer, Margaret S.,Stanton, Josephine A.,Sohal, Bindi,Mortishire-Smith, Russell J.,Castro, Jose L.
, p. 2491 - 2496 (1999)
The conformational restriction of a (benzylamino)methyl substituted pyrrolidine to form 2,7-diazabicyclo[3.3.0]octanes has led to a series of compounds with high affinity at the h5-HT(1D) receptor as well as dramatically increased concentrations in the hepatic portal vein following oral administration.