194995-45-4Relevant articles and documents
Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems
Lin, Yang-I.,Bitha, Panayota,Li, Zhong,Sakya, Subas M.,Strohmeyer, Timothy W.,Lang Jr., Stanley A.,Yang, Youjun,Bhachech, Niraja,Weiss, William J.,Petersen, Peter J.,Jacobus, Nilda V.,Bush, Karen,Testa, Raymond T.
, p. 1811 - 1816 (1997)
Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.